| Literature DB >> 26544765 |
Tian Qin1, Takayuki Iwata1, Tanya T Ransom2, John A Beutler2, John A Porco1.
Abstract
The 2,4'- and 4,4'-linked variants of the cytotoxic agent secalonic acid A and their analogues have been synthesized. Kinetic resolution of an unprotected tetrahydroxanthone scaffold followed by copper-mediated biaryl coupling allowed for efficient access to these compounds. Evaluation of the "shapeshifting" properties of 2,2'-, 2,4'-, and 4,4'-linked variants of the secalonic acids A in a polar solvent in conjunction with assays of the compounds against select cancer cell lines was conducted to study possible correlations between linkage variation and cytotoxicity.Entities:
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Year: 2015 PMID： 26544765 PMCID： PMC4863954 DOI： 10.1021/jacs.5b09825
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419