Literature DB >> 26544122

Drug makers target ubiquitin proteasome pathway anew.

Cormac Sheridan.   

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Year:  2015        PMID： 26544122     DOI： 10.1038/nbt1115-1115

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


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  7 in total

1.  A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.

Authors:  Dharminder Chauhan; Ze Tian; Benjamin Nicholson; K G Suresh Kumar; Bin Zhou; Ruben Carrasco; Jeffrey L McDermott; Craig A Leach; Mariaterresa Fulcinniti; Matthew P Kodrasov; Joseph Weinstock; William D Kingsbury; Teru Hideshima; Parantu K Shah; Stephane Minvielle; Mikael Altun; Benedikt M Kessler; Robert Orlowski; Paul Richardson; Nikhil Munshi; Kenneth C Anderson
Journal:  Cancer Cell       Date:  2012-09-11       Impact factor: 31.743

2.  Identification of a primary target of thalidomide teratogenicity.

Authors:  Takumi Ito; Hideki Ando; Takayuki Suzuki; Toshihiko Ogura; Kentaro Hotta; Yoshimasa Imamura; Yuki Yamaguchi; Hiroshi Handa
Journal:  Science       Date:  2010-03-12       Impact factor: 47.728

3.  Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.

Authors:  A Lopez-Girona; D Mendy; T Ito; K Miller; A K Gandhi; J Kang; S Karasawa; G Carmel; P Jackson; M Abbasian; A Mahmoudi; B Cathers; E Rychak; S Gaidarova; R Chen; P H Schafer; H Handa; T O Daniel; J F Evans; R Chopra
Journal:  Leukemia       Date:  2012-05-03       Impact factor: 11.528

4.  Enhancement of proteasome activity by a small-molecule inhibitor of USP14.

Authors:  Byung-Hoon Lee; Min Jae Lee; Soyeon Park; Dong-Chan Oh; Suzanne Elsasser; Ping-Chung Chen; Carlos Gartner; Nevena Dimova; John Hanna; Steven P Gygi; Scott M Wilson; Randall W King; Daniel Finley
Journal:  Nature       Date:  2010-09-09       Impact factor: 49.962

Review 5.  Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets.

Authors:  Lynn Bedford; James Lowe; Lawrence R Dick; R John Mayer; James E Brownell
Journal:  Nat Rev Drug Discov       Date:  2010-12-10       Impact factor: 84.694

6.  Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).

Authors:  Anita K Gandhi; Jian Kang; Courtney G Havens; Thomas Conklin; Yuhong Ning; Lei Wu; Takumi Ito; Hideki Ando; Michelle F Waldman; Anjan Thakurta; Anke Klippel; Hiroshi Handa; Thomas O Daniel; Peter H Schafer; Rajesh Chopra
Journal:  Br J Haematol       Date:  2013-12-13       Impact factor: 6.998

Review 7.  Development of inhibitors in the ubiquitination cascade.

Authors:  Wei Zhang; Sachdev S Sidhu
Journal:  FEBS Lett       Date:  2013-11-12       Impact factor: 4.124
  7 in total
  5 in total

1.  Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth.

Authors:  Xue Li; Lingmei Kong; Qihong Yang; Aizhu Duan; Xiaoman Ju; Bicheng Cai; Lin Chen; Tao An; Yan Li
Journal:  J Biol Chem       Date:  2020-02-06       Impact factor: 5.157

2.  Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.

Authors:  Gerald Gavory; Colin R O'Dowd; Matthew D Helm; Jakub Flasz; Elias Arkoudis; Anthony Dossang; Caroline Hughes; Eamon Cassidy; Keeva McClelland; Ewa Odrzywol; Natalie Page; Oliver Barker; Hugues Miel; Timothy Harrison
Journal:  Nat Chem Biol       Date:  2017-12-04       Impact factor: 15.040

3.  Structural and Functional Analysis of Ubiquitin-based Inhibitors That Target the Backsides of E2 Enzymes.

Authors:  Pankaj Garg; Derek F Ceccarelli; Alexander F A Keszei; Igor Kurinov; Frank Sicheri; Sachdev S Sidhu
Journal:  J Mol Biol       Date:  2019-10-19       Impact factor: 5.469

4.  An assay for 26S proteasome activity based on fluorescence anisotropy measurements of dye-labeled protein substrates.

Authors:  Sucharita Bhattacharyya; Jonathan P Renn; Houqing Yu; John F Marko; Andreas Matouschek
Journal:  Anal Biochem       Date:  2016-06-11       Impact factor: 3.365

5.  Neural precursor cell expressed, developmentally downregulated 8 promotes tumor progression and predicts poor prognosis of patients with bladder cancer.

Authors:  Da-Wei Tian; Zhou-Liang Wu; Li-Ming Jiang; Jie Gao; Chang-Li Wu; Hai-Long Hu
Journal:  Cancer Sci       Date:  2018-12-10       Impact factor: 6.716
  5 in total

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