Literature DB >> 26542734

Function of Slit/Robo signaling in breast cancer.

Feng Gu1, Yongjie Ma1, Jiao Zhang1, Fengxia Qin1, Li Fu2.   

Abstract

Slit and Robo are considered tumor suppressors because they are frequently inactivated in various tumor tissue. These genes are closely correlated with CpG hypermethylation in their promoters. The Slit/Robo signaling pathway is reportedly involved in breast cancer development and metastasis. Overexpression of Slit/ Robo induces its tumor suppressive effects possibly by inactivating the β-catenin/LEF/TCF and PI3K/Akt signaling pathways or by altering β-catenin/E-cadherin-mediated cell-cell adhesion in breast cancer cells. Furthermore, loss of Slit proteins or their Robo receptors upregulates the CXCL12/CXCR4 signaling axis in human breast carcinoma. In addition, this pathway regulates the distant migration of breast cancer cells not only by mediating the phosphorylation of the downstream molecules of CXCL12/CXCR4 and srGAPs, such as PI3K/ Src, RAFTK/ Pyk2, and CDC42, but also by regulating the activities of MAP kinases. This review includes recent studies on the functions of Slit/Robo signaling in breast cancer and its molecular mechanisms.

Entities:  

Keywords:  CXCL12/CXCR4; Slit/Robo; hypermethylation; migration; β-catenin

Mesh：

Substances：

Year:  2015        PMID： 26542734     DOI： 10.1007/s11684-015-0416-9

Source DB:  PubMed          Journal:  Front Med        ISSN： 2095-0217            Impact factor:   4.592


  38 in total

1.  Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

Authors:  K Wong; X R Ren; Y Z Huang; Y Xie; G Liu; H Saito; H Tang; L Wen; S M Brady-Kalnay; L Mei; J Y Wu; W C Xiong; Y Rao
Journal:  Cell       Date:  2001-10-19       Impact factor: 41.582

Review 2.  RAFTK/Pyk2-mediated cellular signalling.

Authors:  H Avraham; S Y Park; K Schinkmann; S Avraham
Journal:  Cell Signal       Date:  2000-03       Impact factor: 4.315

3.  Structural insights into the Slit-Robo complex.

Authors:  Cecile Morlot; Nicole M Thielens; Raimond B G Ravelli; Wieger Hemrika; Roland A Romijn; Piet Gros; Stephen Cusack; Andrew A McCarthy
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-11       Impact factor: 11.205

4.  Cancer statistics, 1999.

Authors:  S H Landis; T Murray; S Bolden; P A Wingo
Journal:  CA Cancer J Clin       Date:  1999 Jan-Feb       Impact factor: 508.702

5.  SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers.

Authors:  Ashraf Dallol; Nancy Fernandes Da Silva; Paolo Viacava; John D Minna; Ivan Bieche; Eamonn R Maher; Farida Latif
Journal:  Cancer Res       Date:  2002-10-15       Impact factor: 12.701

6.  Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.

Authors:  G P Holmes; K Negus; L Burridge; S Raman; E Algar; T Yamada; M H Little
Journal:  Mech Dev       Date:  1998-12       Impact factor: 1.882

7.  Reduced expression of Slit2 in renal cell carcinoma.

Authors:  Wei-Jie Ma; Yu Zhou; Dan Lu; Dong Dong; Xiao-Jun Tian; Jie-Xi Wen; Jun Zhang
Journal:  Med Oncol       Date:  2013-11-15       Impact factor: 3.064

Review 8.  Structural insight into Slit-Robo signalling.

Authors:  Erhard Hohenester
Journal:  Biochem Soc Trans       Date:  2008-04       Impact factor: 5.407

9.  Slit protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells.

Authors:  Anil Prasad; Aaron Z Fernandis; Yi Rao; Ramesh K Ganju
Journal:  J Biol Chem       Date:  2003-11-26       Impact factor: 5.157

10.  Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers.

Authors:  Ashraf Dallol; Eva Forgacs; Alonso Martinez; Yoshitaka Sekido; Rosemary Walker; Takeshi Kishida; Pamela Rabbitts; Eamonn R Maher; John D Minna; Farida Latif
Journal:  Oncogene       Date:  2002-05-02       Impact factor: 9.867
View more
  7 in total

1.  Identification of direct negative cross-talk between the SLIT2 and bone morphogenetic protein-Gremlin signaling pathways.

Authors:  Kathleen E Tumelty; Nathan Higginson-Scott; Xueping Fan; Piyush Bajaj; Kelly M Knowlton; Michael Shamashkin; Anthony J Coyle; Weining Lu; Stephen P Berasi
Journal:  J Biol Chem       Date:  2018-01-09       Impact factor: 5.157

Review 2.  Extracellular Regulation of the Mitotic Spindle and Fate Determinants Driving Asymmetric Cell Division.

Authors:  Prestina Smith; Mark Azzam; Lindsay Hinck
Journal:  Results Probl Cell Differ       Date:  2017

3.  The Role of miRNAs in the Resistance of Anthracyclines in Breast Cancer: A Systematic Review.

Authors:  Zihan Si; Yan Zhong; Sixian Lao; Yufeng Wu; Guoping Zhong; Weiwei Zeng
Journal:  Front Oncol       Date:  2022-05-12       Impact factor: 5.738

4.  A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis.

Authors:  Iacovos P Michael; Sadegh Saghafinia; Douglas Hanahan
Journal:  Proc Natl Acad Sci U S A       Date:  2019-11-08       Impact factor: 11.205

5.  Comparative proteomic analysis of different stages of breast cancer tissues using ultra high performance liquid chromatography tandem mass spectrometer.

Authors:  Abdullah Saleh Al-Wajeeh; Salizawati Muhamad Salhimi; Majed Ahmed Al-Mansoub; Imran Abdul Khalid; Thomas Michael Harvey; Aishah Latiff; Mohd Nazri Ismail
Journal:  PLoS One       Date:  2020-01-16       Impact factor: 3.240

6.  Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia.

Authors:  Isabel Weinhäuser; Diego A Pereira-Martins; Cesar Ortiz; Douglas R Silveira; Luíse A A Simões; Thiago M Bianco; Cleide L Araujo; Luisa C Koury; Raul A M Melo; Rosane I Bittencourt; Katia Pagnano; Ricardo Pasquini; Elenaide C Nunes; Evandro M Fagundes; Ana B Gloria; Fábio Kerbauy; Maria de Lourdes Chauffaille; Armand Keating; Martin S Tallman; Raul C Ribeiro; Richard Dillon; Arnold Ganser; Bob Löwenberg; Peter Valk; Francesco Lo-Coco; Miguel A Sanz; Nancy Berliner; Emanuele Ammatuna; Antonio R Lucena-Araujo; Jan Jacob Schuringa; Eduardo M Rego
Journal:  Cancers (Basel)       Date:  2020-10-27       Impact factor: 6.639

7.  Mechanistic Targets of Diallyl Trisulfide in Human Breast Cancer Cells Identified by RNA-seq Analysis.

Authors:  Eun-Ryeong Hahm; Su-Hyeong Kim; Sivapar V Mathan; Rana P Singh; Shivendra V Singh
Journal:  J Cancer Prev       Date:  2021-06-30
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.