Matthew P Pase1, Alexa Beiser2, Hugo Aparicio3, Charles DeCarli4, Ramachandran S Vasan3, Joanne Murabito3, Sudha Seshadri3. 1. Boston University School of Medicine & Framingham Heart Study, Boston, MA, USA; Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia. Electronic address: matthewpase@gmail.com. 2. Boston University School of Medicine & Framingham Heart Study, Boston, MA, USA; Boston University School of Public Health, Boston, MA, USA. 3. Boston University School of Medicine & Framingham Heart Study, Boston, MA, USA. 4. Department of Neurology, School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento, CA, USA.
Abstract
INTRODUCTION: This study examined whether interarm differences in systolic blood pressure (IDSBP) ≥10 mm Hg were associated with the risk of incident dementia and subclinical brain injury. METHODS: Between 1992 and 1998, 2063 participants of the Framingham Heart Study underwent assessment of IDSBP with results related to the 10-year risk of incident dementia including clinically characterized Alzheimer's disease. Secondary outcomes included markers of subclinical brain injury on magnetic resonance imaging. RESULTS: High IDSBP were associated with a greater risk of incident dementia (hazard ratio [HR] 1.92; 95% confidence interval [CI], 1.09-3.40) and Alzheimer's disease (HR, 2.32; 95% CI, 1.29-4.18), but only in those who carried an apolipoprotein E (APOE) ε4 allele. IDSBP also predicted lower total brain volumes and more prevalent silent brain infarcts in those who were APOE ε4 positive. DISCUSSION: High IDSBP were associated with an increased risk of dementia, including clinical Alzheimer's disease, and subclinical brain injury in those who were APOE ε4 positive.
INTRODUCTION: This study examined whether interarm differences in systolic blood pressure (IDSBP) ≥10 mm Hg were associated with the risk of incident dementia and subclinical brain injury. METHODS: Between 1992 and 1998, 2063 participants of the Framingham Heart Study underwent assessment of IDSBP with results related to the 10-year risk of incident dementia including clinically characterized Alzheimer's disease. Secondary outcomes included markers of subclinical brain injury on magnetic resonance imaging. RESULTS: High IDSBP were associated with a greater risk of incident dementia (hazard ratio [HR] 1.92; 95% confidence interval [CI], 1.09-3.40) and Alzheimer's disease (HR, 2.32; 95% CI, 1.29-4.18), but only in those who carried an apolipoprotein E (APOE) ε4 allele. IDSBP also predicted lower total brain volumes and more prevalent silent brain infarcts in those who were APOE ε4 positive. DISCUSSION: High IDSBP were associated with an increased risk of dementia, including clinical Alzheimer's disease, and subclinical brain injury in those who were APOE ε4 positive.
Authors: Charles DeCarli; Joseph Massaro; Danielle Harvey; John Hald; Mats Tullberg; Rhoda Au; Alexa Beiser; Ralph D'Agostino; Philip A Wolf Journal: Neurobiol Aging Date: 2005-04 Impact factor: 4.673
Authors: Ido Weinberg; Philimon Gona; Christopher J O'Donnell; Michael R Jaff; Joanne M Murabito Journal: Am J Med Date: 2013-11-25 Impact factor: 4.965
Authors: Mark Yarchoan; Sharon X Xie; Mitchel A Kling; Jon B Toledo; David A Wolk; Edward B Lee; Vivianna Van Deerlin; Virginia M-Y Lee; John Q Trojanowski; Steven E Arnold Journal: Brain Date: 2012-11-30 Impact factor: 13.501
Authors: Connie W Tsao; Sudha Seshadri; Alexa S Beiser; Andrew J Westwood; Charles Decarli; Rhoda Au; Jayandra J Himali; Naomi M Hamburg; Joseph A Vita; Daniel Levy; Martin G Larson; Emelia J Benjamin; Philip A Wolf; Ramachandran S Vasan; Gary F Mitchell Journal: Neurology Date: 2013-08-09 Impact factor: 9.910
Authors: T Polvikoski; R Sulkava; M Haltia; K Kainulainen; A Vuorio; A Verkkoniemi; L Niinistö; P Halonen; K Kontula Journal: N Engl J Med Date: 1995-11-09 Impact factor: 91.245
Authors: Christopher E Clark; Daniel Thomas; David J Llewellyn; Luigi Ferrucci; Stefania Bandinelli; John L Campbell Journal: Br J Gen Pract Date: 2020-06-25 Impact factor: 5.386
Authors: Karri Suvila; Joao A C Lima; Yuichiro Yano; Zaldy S Tan; Susan Cheng; Teemu J Niiranen Journal: Hypertension Date: 2021-01-19 Impact factor: 9.897
Authors: Joel Salinas; Adrienne O'Donnell; Daniel J Kojis; Matthew P Pase; Charles DeCarli; Dorene M Rentz; Lisa F Berkman; Alexa Beiser; Sudha Seshadri Journal: JAMA Netw Open Date: 2021-08-02
Authors: Christopher E Clark; Kate Boddy; Fiona C Warren; Rod S Taylor; Victor Aboyans; Lyne Cloutier; Richard J McManus; Angela C Shore; John L Campbell Journal: BMJ Open Date: 2017-07-02 Impact factor: 2.692