Literature DB >> 265416

Survival of human cells in the aggregate form: potential index of in vitro cell transformation.

A F Steuer, J S Rhim, P M Hentosh, R C Ting.   

Abstract

The ability of cell populations to survive in the aggregate form was compared to colony formation in soft agar and tumorigenicity in nude mice. Nontumorigenic human osteogenic sarcoma (HOS) cells, which formed colonies in soft agar, could not survive in the aggregate form. Tumorigenic HOS cell lines, which also formed colonies in soft agar, survived and proliferated in the aggregate form. Other cell types were tested with the same results. This approach, based on cell survival in the aggregate form, may provide an additional, reliable method for predicting the tumorigenic status of a cell population.

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Year:  1977        PMID： 265416     DOI： 10.1093/jnci/58.4.917

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  5 in total

1.  Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression.

Authors:  David Kozono; Jie Li; Masayuki Nitta; Oltea Sampetrean; David Gonda; Deepa S Kushwaha; Dmitry Merzon; Valya Ramakrishnan; Shan Zhu; Kaya Zhu; Hiroko Matsui; Olivier Harismendy; Wei Hua; Ying Mao; Chang-Hyuk Kwon; Hideyuki Saya; Ichiro Nakano; Donald P Pizzo; Scott R VandenBerg; Clark C Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-09       Impact factor: 11.205

2.  Agglomeration to nodules modulates human arterial smooth muscle cells to distinct postinjury phenotype via foam cell transition.

Authors:  S Björkerud
Journal:  Am J Pathol       Date:  1987-06       Impact factor: 4.307

3.  Establishment and characterization of a new cell line from a hereditary renal rat tumor.

Authors:  P Eker; R Eker; J V Johannessen
Journal:  In Vitro       Date:  1983-06

4.  Neoplastic transformation of chimpanzee cells induced by adenovirus type 12--simian virus 40 hybrid virus.

Authors:  J S Rhim; R Trimmer; P Arnstein; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205

5.  A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for primary isolates of human immunodeficiency virus.

Authors:  Nobuaki Shimizu; Atsushi Tanaka; Takahisa Mori; Takahiro Ohtsuki; Aliful Hoque; Atsushi Jinno-Oue; Chatchawann Apichartpiyakul; Shigeru Kusagawa; Yutaka Takebe; Hiroo Hoshino
Journal:  Retrovirology       Date:  2008-06-25       Impact factor: 4.602
  5 in total

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