| Literature DB >> 26541513 |
Mária Šimášková1,2, José Antonio O'Brien1,2, Mamoona Khan3, Giel Van Noorden1,2, Krisztina Ötvös3, Anne Vieten4, Inge De Clercq1,2, Johanna Maria Adriana Van Haperen5, Candela Cuesta3, Klára Hoyerová6, Steffen Vanneste1,2, Peter Marhavý3, Krzysztof Wabnik3, Frank Van Breusegem1,2, Moritz Nowack1,2, Angus Murphy7, Jiří Friml3, Dolf Weijers5, Tom Beeckman1,2, Eva Benková3.
Abstract
Auxin and cytokinin are key endogenous regulators of plant development. Although cytokinin-mediated modulation of auxin distribution is a developmentally crucial hormonal interaction, its molecular basis is largely unknown. Here we show a direct regulatory link between cytokinin signalling and the auxin transport machinery uncovering a mechanistic framework for cytokinin-auxin cross-talk. We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin perception, transcriptionally control genes encoding PIN-FORMED (PIN) auxin transporters at a specific PIN CYTOKININ RESPONSE ELEMENT (PCRE) domain. Removal of this cis-regulatory element effectively uncouples PIN transcription from the CRF-mediated cytokinin regulation and attenuates plant cytokinin sensitivity. We propose that CRFs represent a missing cross-talk component that fine-tunes auxin transport capacity downstream of cytokinin signalling to control plant development.Mesh：
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Year: 2015 PMID： 26541513 DOI： 10.1038/ncomms9717
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919