Literature DB >> 26541429

Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology.

Amanda N Sacino1,2, Jacob I Ayers1,2,3, Mieu M T Brooks1,2, Paramita Chakrabarty1,2,3, Vincent J Hudson1,2, Jasie K Howard1,2, Todd E Golde1,2,3, Benoit I Giasson4,5,6, David R Borchelt7,8,9.   

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Year:  2015        PMID： 26541429      PMCID： PMC4852859          DOI： 10.1007/s00401-015-1505-1

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


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  9 in total

1.  Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice.

Authors:  Amanda N Sacino; Mieu Brooks; Michael A Thomas; Alex B McKinney; Nicholas H McGarvey; Nicola J Rutherford; Carolina Ceballos-Diaz; Janice Robertson; Todd E Golde; Benoit I Giasson
Journal:  Acta Neuropathol       Date:  2014-05       Impact factor: 17.088

2.  Prion-like acceleration of a synucleinopathy in a transgenic mouse model.

Authors:  Anne-Laure Mougenot; Simon Nicot; Anna Bencsik; Eric Morignat; Jérémy Verchère; Latefa Lakhdar; Stéphane Legastelois; Thierry Baron
Journal:  Neurobiol Aging       Date:  2011-08-03       Impact factor: 4.673

3.  Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

Authors:  Amanda N Sacino; Mieu Brooks; Michael A Thomas; Alex B McKinney; Sooyeon Lee; Robert W Regenhardt; Nicholas H McGarvey; Jacob I Ayers; Lucia Notterpek; David R Borchelt; Todd E Golde; Benoit I Giasson
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-07       Impact factor: 11.205

4.  Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein.

Authors:  Benoit I Giasson; John E Duda; Shawn M Quinn; Bin Zhang; John Q Trojanowski; Virginia M-Y Lee
Journal:  Neuron       Date:  2002-05-16       Impact factor: 17.173

5.  Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.

Authors:  Kelvin C Luk; Victoria M Kehm; Bin Zhang; Patrick O'Brien; John Q Trojanowski; Virginia M Y Lee
Journal:  J Exp Med       Date:  2012-04-16       Impact factor: 14.307

6.  Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.

Authors:  Stanley B Prusiner; Amanda L Woerman; Daniel A Mordes; Joel C Watts; Ryan Rampersaud; David B Berry; Smita Patel; Abby Oehler; Jennifer K Lowe; Stephanie N Kravitz; Daniel H Geschwind; David V Glidden; Glenda M Halliday; Lefkos T Middleton; Steve M Gentleman; Lea T Grinberg; Kurt Giles
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-31       Impact factor: 11.205

7.  Transmission of multiple system atrophy prions to transgenic mice.

Authors:  Joel C Watts; Kurt Giles; Abby Oehler; Lefkos Middleton; David T Dexter; Steve M Gentleman; Stephen J DeArmond; Stanley B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-11       Impact factor: 11.205

8.  Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.

Authors:  Nicola J Rutherford; Amanda N Sacino; Mieu Brooks; Carolina Ceballos-Diaz; Thomas B Ladd; Jasie K Howard; Todd E Golde; Benoit I Giasson
Journal:  Mol Neurodegener       Date:  2015-07-30       Impact factor: 14.195

9.  Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.

Authors:  Dominique Bétemps; Jérémy Verchère; Sébastien Brot; Eric Morignat; Luc Bousset; Damien Gaillard; Latifa Lakhdar; Ronald Melki; Thierry Baron
Journal:  Acta Neuropathol Commun       Date:  2014-03-13       Impact factor: 7.801
  9 in total
  11 in total

1.  Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.

Authors:  Jacob I Ayers; Mieu M Brooks; Nicola J Rutherford; Jasie K Howard; Zachary A Sorrentino; Cara J Riffe; Benoit I Giasson
Journal:  J Virol       Date:  2017-01-03       Impact factor: 5.103

Review 2.  Parkinson's Disease Is Not Simply a Prion Disorder.

Authors:  D James Surmeier; José A Obeso; Glenda M Halliday
Journal:  J Neurosci       Date:  2017-10-11       Impact factor: 6.167

3.  Transmissible α-synuclein seeding activity in brain and stomach of patients with Parkinson's disease.

Authors:  Achim Thomzig; Katja Wagenführ; Phillip Pinder; Marion Joncic; Walter J Schulz-Schaeffer; Michael Beekes
Journal:  Acta Neuropathol       Date:  2021-04-24       Impact factor: 17.088

4.  Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.

Authors:  Nelson Ferreira; Hjalte Gram; Zachary A Sorrentino; Emil Gregersen; Sissel Ida Schmidt; Lasse Reimer; Cristine Betzer; Clara Perez-Gozalbo; Marjo Beltoja; Madhu Nagaraj; Jie Wang; Jan S Nowak; Mingdong Dong; Katarina Willén; Ersoy Cholak; Kaare Bjerregaard-Andersen; Nicolas Mendez; Prakruti Rabadia; Mohammad Shahnawaz; Claudio Soto; Daniel E Otzen; Ümit Akbey; Morten Meyer; Benoit I Giasson; Marina Romero-Ramos; Poul Henning Jensen
Journal:  Acta Neuropathol       Date:  2021-05-12       Impact factor: 17.088

Review 5.  Phenotypic diversity in ALS and the role of poly-conformational protein misfolding.

Authors:  Jacob I Ayers; David R Borchelt
Journal:  Acta Neuropathol       Date:  2020-09-15       Impact factor: 15.887

6.  Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.

Authors:  Zachary A Sorrentino; Mieu M T Brooks; Vincent Hudson; Nicola J Rutherford; Todd E Golde; Benoit I Giasson; Paramita Chakrabarty
Journal:  Mol Neurodegener       Date:  2017-05-29       Impact factor: 14.195

7.  Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice.

Authors:  Emily J Koller; Mieu M T Brooks; Todd E Golde; Benoit I Giasson; Paramita Chakrabarty
Journal:  Mol Neurodegener       Date:  2017-01-03       Impact factor: 14.195

8.  Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment.

Authors:  Ayami Okuzumi; Masaru Kurosawa; Taku Hatano; Masashi Takanashi; Shuuko Nojiri; Takeshi Fukuhara; Tomoyuki Yamanaka; Haruko Miyazaki; Saki Yoshinaga; Yoshiaki Furukawa; Tomomi Shimogori; Nobutaka Hattori; Nobuyuki Nukina
Journal:  Acta Neuropathol Commun       Date:  2018-09-19       Impact factor: 7.801

9.  Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes.

Authors:  Juan F Reyes; Christopher Sackmann; Alana Hoffmann; Per Svenningsson; Jürgen Winkler; Martin Ingelsson; Martin Hallbeck
Journal:  Acta Neuropathol       Date:  2019-04-11       Impact factor: 17.088

10.  Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation.

Authors:  Nicole Groh; Anika Bühler; Chaolie Huang; Ka Wan Li; Pim van Nierop; August B Smit; Marcus Fändrich; Frank Baumann; Della C David
Journal:  Front Aging Neurosci       Date:  2017-05-17       Impact factor: 5.750
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