OBJECTIVES: This case series examined the therapeutic potential of repetitive transcranial magnetic stimulation in five women with enduring anorexia nervosa. METHODS: Participants received ~20 sessions of neuronavigated high-frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex. Body mass index, eating disorder (ED) symptoms and mood were assessed pre-treatment and post-treatment, at 6-month and 12-month follow-up (FU). Qualitative feedback regarding the intervention was obtained from participants and carers. RESULTS: From pre-treatment to post-treatment, ED and affective symptoms improved significantly, and body mass index remained stable. Further improvements in ED symptoms/mood were seen at 6-month FU with 3/5 and 2/5 participants deemed 'recovered' on the Eating Disorders Examination Questionnaire and Depression, Anxiety and Stress Scale, respectively. However, most participants had lost some weight, and therapeutic effects on psychopathology had waned by 12-month FU. Qualitative feedback regarding the intervention was encouraging. DISCUSSION: Repetitive transcranial magnetic stimulation was well tolerated, and preliminary evidence is provided for its therapeutic potential in anorexia nervosa.
OBJECTIVES: This case series examined the therapeutic potential of repetitive transcranial magnetic stimulation in five women with enduring anorexia nervosa. METHODS: Participants received ~20 sessions of neuronavigated high-frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex. Body mass index, eating disorder (ED) symptoms and mood were assessed pre-treatment and post-treatment, at 6-month and 12-month follow-up (FU). Qualitative feedback regarding the intervention was obtained from participants and carers. RESULTS: From pre-treatment to post-treatment, ED and affective symptoms improved significantly, and body mass index remained stable. Further improvements in ED symptoms/mood were seen at 6-month FU with 3/5 and 2/5 participants deemed 'recovered' on the Eating Disorders Examination Questionnaire and Depression, Anxiety and Stress Scale, respectively. However, most participants had lost some weight, and therapeutic effects on psychopathology had waned by 12-month FU. Qualitative feedback regarding the intervention was encouraging. DISCUSSION: Repetitive transcranial magnetic stimulation was well tolerated, and preliminary evidence is provided for its therapeutic potential in anorexia nervosa.
Authors: Alexandra F Muratore; Mariya Bershad; Joanna E Steinglass; Karin E Foerde; Loren Gianini; Allegra Broft; Evelyn Attia Journal: Int J Eat Disord Date: 2021-08-20 Impact factor: 5.791
Authors: I Wolz; A Sauvaget; R Granero; G Mestre-Bach; M Baño; V Martín-Romera; M Veciana de Las Heras; S Jiménez-Murcia; A Jansen; A Roefs; F Fernández-Aranda Journal: Sci Rep Date: 2017-02-03 Impact factor: 4.379
Authors: Jessica McClelland; Maria Kekic; Natali Bozhilova; Steffen Nestler; Tracy Dew; Frederique Van den Eynde; Anthony S David; Katya Rubia; Iain C Campbell; Ulrike Schmidt Journal: PLoS One Date: 2016-03-23 Impact factor: 3.240