| Literature DB >> 2653716 |
Y Aujard1, F Brion, E Jacqz-Aigrain, M C Kasse, P Chretien, C Criqui, H Mathieu.
Abstract
A study of the pharmacokinetic parameters of cefotaxime (CTX) and desacetylcefotaxime (dCTX) in newborns was conducted; the former is commonly used for neonatal infections. The elimination half life of CTX correlated with gestational age (GA) and postnatal age (PNA). Elimination of dCTX was longer permitting a synergistic or additive effect with CTX against Gram-negative bacteria. CTX is indicated in the treatment of neonatal sepsis because of the increasing resistance of Escherichia coli to ampicillin and its good efficacy against group B streptococcus.Entities:
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Year: 1989 PMID： 2653716 DOI： 10.1016/0732-8893(89)90051-5
Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803