Literature DB >> 26536486

Metabolic Mechanisms of Drug Resistance in Leukemia.

Birgit Knoechel1, Jon C Aster2.   

Abstract

Tumor cells frequently undergo metabolic reprogramming, but it is unknown how these metabolic changes relate to drug resistance. A recent article now demonstrates that PI3K/AKT signaling causes a metabolic switch from glutaminolysis to aerobic glycolysis in Notch-dependent T cell acute lymphoblastic leukemia (T-ALL).
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26536486     DOI： 10.1016/j.cmet.2015.10.005

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  4 in total

Review 1.  Anticancer drug resistance: An update and perspective.

Authors:  Ruth Nussinov; Chung-Jung Tsai; Hyunbum Jang
Journal:  Drug Resist Updat       Date:  2021-12-16       Impact factor: 18.500

Review 2.  The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought.

Authors:  Angela Ianniciello; Kevin M Rattigan; G Vignir Helgason
Journal:  Front Cell Dev Biol       Date:  2018-09-26

Review 3.  PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers.

Authors:  Rui Liu; Youwen Chen; Guangzhi Liu; Chenxi Li; Yurong Song; Zhiwen Cao; Wen Li; Jinghong Hu; Cheng Lu; Yuanyan Liu
Journal:  Cell Death Dis       Date:  2020-09-24       Impact factor: 8.469

Review 4.  Strategies for having a more effective and less toxic CAR T-cell therapy for acute lymphoblastic leukemia.

Authors:  Mohadese Hashem Boroojerdi; Fatemeh Rahbarizadeh; Pouya Safarzadeh Kozani; Elahe Kamali; Pooria Safarzadeh Kozani
Journal:  Med Oncol       Date:  2020-10-12       Impact factor: 3.064
  4 in total

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