Jacques Donnez1, Pablo Arriagada, Olivier Donnez, Marie-Madeleine Dolmans. 1. aSRI, Société de Recherche pour l'Infertilité, Brussels, Belgium bPregLem SA, Plan-les-ouates, Switzerland cPôle de Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Woluwe-Saint-Lambert, Brussels, Belgium dPolyclinique Urbain V, Avignon, France eCliniques Universitaires Saint-Luc, Service de Gynécologie, Bruxelles, Belgium.
Abstract
PURPOSE OF REVIEW: To review the current management of myomas with the advent of selective progesterone receptor modulators. RECENT FINDINGS: Selective progesterone receptor modulators have proved effective and recent publications on the use of ulipristal acetate (UPA) have analyzed the performance of long-term intermittent utilization of 10 mg UPA given in repeated courses of 3 months. This long-term intermittent therapy maximizes the efficacy of UPA. Indeed, control of bleeding is achieved sooner after each course. With each subsequent course, a statistically greater number of patients show a fibroid volume reduction of more than 50%. SUMMARY: The choice of therapy is influenced by different factors, such as the severity of symptoms, tumor characteristics, age, and wish to preserve the uterus (and fertility). Use of UPA will undoubtedly modify the surgical approach.
PURPOSE OF REVIEW: To review the current management of myomas with the advent of selective progesterone receptor modulators. RECENT FINDINGS: Selective progesterone receptor modulators have proved effective and recent publications on the use of ulipristal acetate (UPA) have analyzed the performance of long-term intermittent utilization of 10 mg UPA given in repeated courses of 3 months. This long-term intermittent therapy maximizes the efficacy of UPA. Indeed, control of bleeding is achieved sooner after each course. With each subsequent course, a statistically greater number of patients show a fibroid volume reduction of more than 50%. SUMMARY: The choice of therapy is influenced by different factors, such as the severity of symptoms, tumor characteristics, age, and wish to preserve the uterus (and fertility). Use of UPA will undoubtedly modify the surgical approach.
Authors: Thomas Rabe; Nicole Saenger; Andreas D Ebert; Thomas Roemer; Hans-Rudolf Tinneberg; Rudy Leon De Wilde; Markus Wallwiener Journal: Biomed Res Int Date: 2018-06-24 Impact factor: 3.411
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