Stefano R Giannubilo1, Andrea Ciavattini, Felice Petraglia, Mario Castellucci, Pasquapina Ciarmela. 1. aDepartment of Clinical Science, Polytechnic University of Marche, Ancona bDepartment of Molecular and Developmental Medicine, Obstetrics, and Gynecology, University of Siena, Siena cDepartment of Experimental and Clinical Medicine, Faculty of Medicine dDepartment of Information Engineering, Polytechnic University of Marche, Ancona, Italy *Mario Castellucci and Pasquapina Ciarmela contributed equally to the writing of this article.
Abstract
PURPOSE OF REVIEW: This article reviews fibroids management in the perimenopausal period, and addresses future directions in care. RECENT FINDINGS: Aromatase inhibitors, selective estrogen receptor modulators and antiprogestogens for medical management and minimally surgical techniques are promising treatments. SUMMARY: The disease and the symptoms may persist in the peri and postmenopausal periods. The assumption that they will resolve with the onset of the menopause is too simplistic and not always valid. The number of perimenopausal women who wish to retain their uterus for reasons other than childbearing is increasing. The accurate diagnosis of these conditions may result in minor surgical or medical treatments being directed at the specific pathology and may avoid the need for major surgery.
PURPOSE OF REVIEW: This article reviews fibroids management in the perimenopausal period, and addresses future directions in care. RECENT FINDINGS: Aromatase inhibitors, selective estrogen receptor modulators and antiprogestogens for medical management and minimally surgical techniques are promising treatments. SUMMARY: The disease and the symptoms may persist in the peri and postmenopausal periods. The assumption that they will resolve with the onset of the menopause is too simplistic and not always valid. The number of perimenopausal women who wish to retain their uterus for reasons other than childbearing is increasing. The accurate diagnosis of these conditions may result in minor surgical or medical treatments being directed at the specific pathology and may avoid the need for major surgery.