Literature DB >> 2653310

An illustration of the use of isotopes: the biosynthesis of porphyrins.

D Shemin.   

Abstract

In this article, David Shemin, who is now in retirement, describes how in 1944 he ingested 66 g of 15N-labeled glycine in order to determine the half-life of hemoglobin and other blood proteins. The ramifications of the experiment led to the unravelling of the biosynthesis of porphyrins and the role of glycine and alpha-aminolevulinic acid in heme, vitamin B12 and chlorophyll synthesis.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2653310     DOI： 10.1002/bies.950100108

Source DB:  PubMed          Journal:  Bioessays        ISSN： 0265-9247            Impact factor:   4.345


  3 in total

Review 1.  5-aminolevulinate synthase: catalysis of the first step of heme biosynthesis.

Authors:  G A Hunter; G C Ferreira
Journal:  Cell Mol Biol (Noisy-le-grand)       Date:  2009-02-16       Impact factor: 1.770

2.  A dicarboxylate/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic Archaeum Ignicoccus hospitalis.

Authors:  Harald Huber; Martin Gallenberger; Ulrike Jahn; Eva Eylert; Ivan A Berg; Daniel Kockelkorn; Wolfgang Eisenreich; Georg Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-29       Impact factor: 11.205

Review 3.  Heme Catabolic Pathway in Inflammation and Immune Disorders.

Authors:  Bing Wu; Yanwei Wu; Wei Tang
Journal:  Front Pharmacol       Date:  2019-07-24       Impact factor: 5.810
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.