Literature DB >> 2653233

Detection of drug resistance in human ovarian carcinoma.

M Volm1, T Efferth, M Bak, J Mattern.   

Abstract

Drug-resistant cancer cells with the multidrug-resistance phenotype show overexpression of P-glycoprotein, and we therefore tested carcinoma tissue from five patients with stage III or IV ovarian cancer for P-glycoprotein using 265/F4 and C 219 monoclonal antibodies, prepared against membrane glycoproteins in colchicine-resistant CHO cells. Using immunofluorescence and immunoblotting techniques, one of the tumors showed a positive reaction. Using the pcDR 1.5 clone we found that the same cancer tissue had elevated expression of the genes responsible for multidrug resistance. The demonstration of elevated P-glycoprotein in ovarian carcinomas indicates that P-glycoprotein overexpression is not limited to experimental tumor models.

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Year:  1989        PMID： 2653233     DOI： 10.1007/bf00931383

Source DB:  PubMed          Journal:  Arch Gynecol Obstet        ISSN： 0932-0067            Impact factor:   2.344


  26 in total

1.  Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

Authors:  P Gros; J Croop; I Roninson; A Varshavsky; D E Housman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

2.  Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.

Authors:  G Fairbanks; T L Steck; D F Wallach
Journal:  Biochemistry       Date:  1971-06-22       Impact factor: 3.162

3.  Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells.

Authors:  K Dano
Journal:  Biochim Biophys Acta       Date:  1973-10-25

4.  Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

Authors:  W T Beck; T J Mueller; L R Tanzer
Journal:  Cancer Res       Date:  1979-06       Impact factor: 12.701

5.  Membrane alterations associated with progressive adriamycin resistance.

Authors:  C Wheeler; R Rader; D Kessel
Journal:  Biochem Pharmacol       Date:  1982-08-15       Impact factor: 5.858

6.  Pretherapeutic detection of tumour resistance and the results of tumour chemotherapy.

Authors:  M Volm; K Wayss; M Kaufmann; J Mattern
Journal:  Eur J Cancer       Date:  1979-07       Impact factor: 9.162

7.  Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

Authors:  J R Riordan; V Ling
Journal:  J Biol Chem       Date:  1979-12-25       Impact factor: 5.157

8.  The role of membranes in the mechanism of action of the antineoplastic agent adriamycin. Spin-labeling studies with chronically hypoxic and drug-resistant tumor cells.

Authors:  J A Siegfried; K A Kennedy; A C Sartorelli; T R Tritton
Journal:  J Biol Chem       Date:  1983-01-10       Impact factor: 5.157

9.  Induced multidrug-resistance in murine sarcoma 180 cells grown in vitro and in vivo and associated changes in expression of multidrug-resistance DNA-sequences and membrane glycoproteins.

Authors:  M Volm; M Bak; T Efferth; J Mattern
Journal:  Anticancer Res       Date:  1988 Nov-Dec       Impact factor: 2.480

10.  Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance.

Authors:  D R Bell; J H Gerlach; N Kartner; R N Buick; V Ling
Journal:  J Clin Oncol       Date:  1985-03       Impact factor: 44.544
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  1 in total

1.  Expression of a human multidrug resistance gene in human ovarian carcinoma cell lines.

Authors:  S Sekiya; T Nunoyama; H Shirasawa; H Kimura; M Kawata; N Iijima; Y Sugimoto; T Tsuruo; H Takamizawa
Journal:  Arch Gynecol Obstet       Date:  1992       Impact factor: 2.344
  1 in total

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