Xiang Wang1, Luosheng Tang2, Ling Gao2, Yujia Yang2, Dan Cao2, Yunping Li3. 1. Cancer Research Institute, Central South University, Changsha 410078, Hunan, China; Department of Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China. 2. Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China; Eye Research Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. 3. Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China; Eye Research Institute, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address: amyli@csu.edu.cn.
Abstract
AIMS: Myopia may have protective effects against diabetic retinopathy (DR). However, the data from epidemiologic studies are inconsistent. We aimed to examine the association between myopia and DR by conducting a meta-analysis. METHODS: We identified studies by searching the PubMed and EMBASE databases. Study-specific odds ratios (ORs) were pooled using a fixed or random effects model. Myopic eyes were defined as having a spherical equivalent (SE)<-0.5 diopters (D). Myopic SE, each diopter decrease in SE toward myopia, and each millimeter increase in axial length (AL) were used as independent surrogate variables for myopia. RESULTS: Data from 6 population-based and 3 clinic-based studies were included in the analyses. Myopic SE (compared with emmetropic eyes) and each millimeter increase in AL were associated with a decreased risk for DR (pooled odds ratio [OR], 0.80 and 0.79, respectively; 95% confidence interval [CI], 0.67-0.95 and 0.73-0.86, respectively; P=0.011 and 0.000, respectively). Each millimeter increase in AL was also associated with a decreased risk for vision-threatening diabetic retinopathy (VTDR) (pooled OR, 0.70; 95% CI, 0.60-0.82; P=0.000). No significant association between each diopter decrease in SE and DR was observed. CONCLUSIONS: Our meta-analysis suggests that individuals with myopia exhibit a decreased risk of developing DR or VTDR. An increased AL plays a critical role in this protective effect.
AIMS: Myopia may have protective effects against diabetic retinopathy (DR). However, the data from epidemiologic studies are inconsistent. We aimed to examine the association between myopia and DR by conducting a meta-analysis. METHODS: We identified studies by searching the PubMed and EMBASE databases. Study-specific odds ratios (ORs) were pooled using a fixed or random effects model. Myopic eyes were defined as having a spherical equivalent (SE)<-0.5 diopters (D). Myopic SE, each diopter decrease in SE toward myopia, and each millimeter increase in axial length (AL) were used as independent surrogate variables for myopia. RESULTS: Data from 6 population-based and 3 clinic-based studies were included in the analyses. Myopic SE (compared with emmetropic eyes) and each millimeter increase in AL were associated with a decreased risk for DR (pooled odds ratio [OR], 0.80 and 0.79, respectively; 95% confidence interval [CI], 0.67-0.95 and 0.73-0.86, respectively; P=0.011 and 0.000, respectively). Each millimeter increase in AL was also associated with a decreased risk for vision-threatening diabetic retinopathy (VTDR) (pooled OR, 0.70; 95% CI, 0.60-0.82; P=0.000). No significant association between each diopter decrease in SE and DR was observed. CONCLUSIONS: Our meta-analysis suggests that individuals with myopia exhibit a decreased risk of developing DR or VTDR. An increased AL plays a critical role in this protective effect.
Authors: Jacquelyn N Hamati; Anthony Vipin Das; Gumpili Sai Prashanthi; Umesh C Behera; Raja Narayanan; Padmaja K Rani Journal: Indian J Ophthalmol Date: 2021-11 Impact factor: 2.969
Authors: Erica W T Kung; Victor T T Chan; Ziqi Tang; Dawei Yang; Zihan Sun; Yu Meng Wang; C H Chan; Michael C H Kwan; Jian Shi; Carol Y Cheung Journal: Ophthalmol Sci Date: 2022-02-25