| Literature DB >> 26530074 |
S V Shirshev1, I V Nekrasova2, O L Gorbunova2, E G Orlova2, I L Maslennikova2.
Abstract
The effect of kisspeptin at concentrations typical of pregnancy on the functional activity of isolated cytokine-primed NK cells has been investigated. The hormone has been shown to promote an increase in the proportion of CD56(bright) NK cells, as well as an increase in the L-selectin expression on the cell surface. Assessment of cytokine levels has shown that kisspeptin suppresses the production of IL-4, IL-10, and IFN-γ while stimulating the production of TGF-β by isolated NK cells. The overall effect of the hormone investigated consisted in the formation of a phenotype and a cytokine spectrum characteristic of the regulatory NK3 subpopulation of NK cells in pregnancy.Entities:
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Year: 2015 PMID： 26530074 DOI： 10.1134/S0012496615050129
Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966