GOAL: Develop and characterize the functionality of a novel thin-film probe technology with a higher density of electrode contacts than are currently available with commercial deep brain stimulation (DBS) lead technology. Such technology has potential to enhance the spatial precision of DBS and enable a more robust approach to sensing local field potential activity in the context of adaptive DBS strategies. METHODS: Thin-film planar arrays were microfabricated and then assembled on a cylindrical carrier to achieve a lead with 3-D conformation. Using an integrated and removable stylet, the arrays were chronically implanted in the subthalamic nucleus and globus pallidus in two parkinsonian nonhuman primates. RESULTS: This study provides the first in vivo data from chronically implanted DBS arrays for translational nonhuman primate studies. Stimulation through the arrays induced a decrease in parkinsonian rigidity, and directing current around the lead showed an orientation dependence for eliciting motor capsule side effects. The array recordings also showed that oscillatory activity in the basal ganglia is heterogeneous at a smaller scale than detected by the current DBS lead technology. CONCLUSION: These 3-D DBS arrays provide an enabling tool for future studies that seek to monitor and modulate deep brain activity through chronically implanted leads. SIGNIFICANCE: DBS lead technology with a higher density of electrode contacts has potential to enable sculpting DBS current flow and sensing biomarkers of disease and therapy.
GOAL: Develop and characterize the functionality of a novel thin-film probe technology with a higher density of electrode contacts than are currently available with commercial deep brain stimulation (DBS) lead technology. Such technology has potential to enhance the spatial precision of DBS and enable a more robust approach to sensing local field potential activity in the context of adaptive DBS strategies. METHODS: Thin-film planar arrays were microfabricated and then assembled on a cylindrical carrier to achieve a lead with 3-D conformation. Using an integrated and removable stylet, the arrays were chronically implanted in the subthalamic nucleus and globus pallidus in two parkinsonian nonhuman primates. RESULTS: This study provides the first in vivo data from chronically implanted DBS arrays for translational nonhuman primate studies. Stimulation through the arrays induced a decrease in parkinsonian rigidity, and directing current around the lead showed an orientation dependence for eliciting motor capsule side effects. The array recordings also showed that oscillatory activity in the basal ganglia is heterogeneous at a smaller scale than detected by the current DBS lead technology. CONCLUSION: These 3-D DBS arrays provide an enabling tool for future studies that seek to monitor and modulate deep brain activity through chronically implanted leads. SIGNIFICANCE: DBS lead technology with a higher density of electrode contacts has potential to enable sculpting DBS current flow and sensing biomarkers of disease and therapy.
Authors: H C F Martens; E Toader; M M J Decré; D J Anderson; R Vetter; D R Kipke; Kenneth B Baker; Matthew D Johnson; Jerrold L Vitek Journal: Clin Neurophysiol Date: 2010-08-21 Impact factor: 3.708
Authors: Scott F Lempka; Svjetlana Miocinovic; Matthew D Johnson; Jerrold L Vitek; Cameron C McIntyre Journal: J Neural Eng Date: 2009-06-03 Impact factor: 5.379
Authors: L J Bour; M A J Lourens; R Verhagen; R M A de Bie; P van den Munckhof; P R Schuurman; M F Contarino Journal: Brain Stimul Date: 2015-02-13 Impact factor: 8.955
Authors: Paul Krack; Jonathan Dostrovsky; Igor Ilinsky; Kristy Kultas-Ilinsky; Fred Lenz; Andres Lozano; Jerry Vitek Journal: Mov Disord Date: 2002 Impact factor: 10.338
Authors: Simeng Zhang; Allison T Connolly; Lauren R Madden; Jerrold L Vitek; Matthew D Johnson Journal: J Neural Eng Date: 2018-04-13 Impact factor: 5.379
Authors: Lauri J Lehto; Julia P Slopsema; Matthew D Johnson; Artem Shatillo; Benjamin A Teplitzky; Lynn Utecht; Gregor Adriany; Silvia Mangia; Alejandra Sierra; Walter C Low; Olli Gröhn; Shalom Michaeli Journal: J Neural Eng Date: 2017-01-09 Impact factor: 5.379
Authors: AnneMarie K Brinda; Alex M Doyle; Madeline Blumenfeld; Jordan Krieg; Joseph S R Alisch; Chelsea Spencer; Emily Lecy; Lucius K Wilmerding; Adele DeNicola; Luke A Johnson; Jerrold L Vitek; Matthew D Johnson Journal: J Neural Eng Date: 2021-05-13 Impact factor: 5.379
Authors: YiZi Xiao; Filippo Agnesi; Edward M Bello; Simeng Zhang; Jerrold L Vitek; Matthew D Johnson Journal: Sci Rep Date: 2018-02-01 Impact factor: 4.379