| Literature DB >> 26529387 |
Diana Olteanu1, Adriana Filip2, Crina Socaci3, Alexandru Radu Biris3, Xenia Filip3, Maria Coros3, Marcela Corina Rosu3, Florina Pogacean3, Camelia Alb4, Ioana Baldea1, Pompei Bolfa5, Stela Pruneanu6.
Abstract
Graphene-oxide (GO) and its most encountered derivatives, thermally reduced graphene oxide (TRGO) and nitrogen-doped graphene (N-Gr), were synthesized and structurally characterized by spectroscopic techniques, like Raman and (13)C MAS solid state NMR. Several biological effects (cytotoxicity, oxidative stress induction, and cellular and mithocondrial membrane alterations) induced by such graphene-based materials on human dental follicle stem cells were investigated. Graphene oxide shows the lowest cytotoxic effect, followed by the nitrogen-doped graphene, while thermally reduced graphene oxide exhibits high cytotoxic effects. Graphene oxide induces oxidative stress without causing cell membrane damage. Nitrogen-doped graphene shows a slight antioxidant activity; however, at high doses (20 and 40 μg/ml) it causes membrane damage. Both graphene oxide and nitrogen-doped graphene seem to be valuable candidates for usage in dental nanocomposites.Entities:
Keywords: Cytotoxicity assessment; Graphene based nanomaterials; Human dental follicle stem cells
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Year: 2015 PMID： 26529387 DOI： 10.1016/j.colsurfb.2015.10.023
Source DB: PubMed Journal: Colloids Surf B Biointerfaces ISSN： 0927-7765 Impact factor: 5.268