Literature DB >> 2652877

Hypothermia: an unusual side effect of paracetamol.

T Van Tittelboom1, M Govaerts-Lepicard.   

Abstract

We report 4 cases of children who presented hypothermia after normal therapeutic doses of paracetamol. Possible mechanisms of the antipyretic action of paracetamol are reviewed in an attempt to explain this rather exceptional description. Comparison is made with other cases in the literature and the experiences of other Poison Control Centers.

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Year:  1989        PMID： 2652877

Source DB:  PubMed          Journal:  Vet Hum Toxicol        ISSN： 0145-6296


  5 in total

1.  Hypothermia induced by therapeutic doses of antipyretics: misdiagnosis of cold sepsis.

Authors:  Indranil Dey; Natasha Singhal; Hannah Ruth Walsh; Paul Anthony Heaton; Siba Prosad Paul
Journal:  Sudan J Paediatr       Date:  2021

Review 2.  Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action.

Authors:  Samir S Ayoub
Journal:  Temperature (Austin)       Date:  2021-03-16

3.  Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.

Authors:  Samir S Ayoub; Regina M Botting; Sarita Goorha; Paul R Colville-Nash; Derek A Willoughby; Leslie R Ballou
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-19       Impact factor: 11.205

4.  Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress.

Authors:  Josh Foster; Alexis R Mauger; Andrew Govus; David Hewson; Lee Taylor
Journal:  Clin Drug Investig       Date:  2017-11       Impact factor: 2.859

5.  Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant.

Authors:  Shuxin Li; Wenkai Dou; Ying Tang; Sarita Goorha; Leslie R Ballou; Clark M Blatteis
Journal:  Prostaglandins Other Lipid Mediat       Date:  2007-11-12       Impact factor: 3.072
  5 in total

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