Literature DB >> 26526946

The Role of Pyruvate Kinase M2 in Cancer Metabolism.

Vivian M Liu1,2, Matthew G Vander Heiden1,3.   

Abstract

The M2 isoform of pyruvate kinase is expressed preferentially in cancer cells over other pyruvate kinase isoforms. PKM2 is unique in its ability to be regulated allosterically by nutrients and growth signaling pathways, allowing cells to adapt their metabolic program to match physiological needs in different environments. Here, we discuss the role of pyruvate kinase M2 in glioma and in cancer metabolism.
© 2015 International Society of Neuropathology.

Entities:  

Keywords:  cancer metabolism; glycolysis; pyruvate kinase M2

Mesh：

Substances：

Year:  2015        PMID： 26526946     DOI： 10.1111/bpa.12311

Source DB:  PubMed          Journal:  Brain Pathol        ISSN： 1015-6305            Impact factor:   6.508


  16 in total

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3.  PKM2 Is Overexpressed in Glioma Tissues, and Its Inhibition Highly Increases Late Apoptosis in U87MG Cells With Low-density Specificity.

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6.  Metabolic Reprogramming in Brain Cancer: A Coordinated Effort.

Authors:  Sriram Venneti; Paul S Mischel
Journal:  Brain Pathol       Date:  2015-11       Impact factor: 6.508

7.  Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice.

Authors:  Dongdong Chen; Ling Wei; Zhi-Ren Liu; Jenny J Yang; Xiaohuan Gu; Zheng Z Wei; Li-Ping Liu; Shan Ping Yu
Journal:  Neurotherapeutics       Date:  2018-07       Impact factor: 7.620

Review 8.  A short review on cross-link between pyruvate kinase (PKM2) and Glioblastoma Multiforme.

Authors:  Harkomal Verma; Ravi P Cholia; Sharanjot Kaur; Monisha Dhiman; Anil K Mantha
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Review 9.  Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents.

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Review 10.  Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring.

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