Marco Armando1, Maria Pontillo2, Franco De Crescenzo2, Luigi Mazzone2, Elena Monducci2, Nella Lo Cascio3, Ornella Santonastaso2, Maria Laura Pucciarini2, Stefano Vicari2, Benno G Schimmelmann4, Frauke Schultze-Lutter4. 1. Child and Adolescence Neuropsychiatry Unit, Department of Neuroscience, Children Hospital Bambino Gesù, Piazza Sant'Onofrio 4, 00100 Rome, Italy; Office Médico-Pédagogique Research Unit, Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland. Electronic address: marco.armando@opbg.net. 2. Child and Adolescence Neuropsychiatry Unit, Department of Neuroscience, Children Hospital Bambino Gesù, Piazza Sant'Onofrio 4, 00100 Rome, Italy. 3. Child and Adolescence Neuropsychiatry Unit, Department of Neuroscience, Children Hospital Bambino Gesù, Piazza Sant'Onofrio 4, 00100 Rome, Italy; Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy. 4. University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bolligenstrasse 111 (Haus A), 3000 Bern 60, Switzerland.
Abstract
OBJECTIVE: The validity of current ultra-high risk (UHR) criteria is under-examined in help-seeking minors, particularly, in children below the age of 12 years. Thus, the present study investigated predictors of one-year outcome in children and adolescents (CAD) with UHR status. METHOD: Thirty-five children and adolescents (age 9-17 years) meeting UHR criteria according to the Structured Interview for Psychosis-Risk Syndromes were followed-up for 12 months. Regression analyses were employed to detect baseline predictors of conversion to psychosis and of outcome of non-converters (remission and persistence of UHR versus conversion). RESULTS: At one-year follow-up, 20% of patients had developed schizophrenia, 25.7% had remitted from their UHR status that, consequently, had persisted in 54.3%. No patient had fully remitted from mental disorders, even if UHR status was not maintained. Conversion was best predicted by any transient psychotic symptom and a disorganized communication score. No prediction model for outcome beyond conversion was identified. CONCLUSIONS: Our findings provide the first evidence for the predictive utility of UHR criteria in CAD in terms of brief intermittent psychotic symptoms (BIPS) when accompanied by signs of cognitive impairment, i.e. disorganized communication. However, because attenuated psychotic symptoms (APS) related to thought content and perception were indicative of non-conversion at 1-year follow-up, their use in early detection of psychosis in CAD needs further study. Overall, the need for more in-depth studies into developmental peculiarities in the early detection and treatment of psychoses with an onset of illness in childhood and early adolescence was further highlighted.
OBJECTIVE: The validity of current ultra-high risk (UHR) criteria is under-examined in help-seeking minors, particularly, in children below the age of 12 years. Thus, the present study investigated predictors of one-year outcome in children and adolescents (CAD) with UHR status. METHOD: Thirty-five children and adolescents (age 9-17 years) meeting UHR criteria according to the Structured Interview for Psychosis-Risk Syndromes were followed-up for 12 months. Regression analyses were employed to detect baseline predictors of conversion to psychosis and of outcome of non-converters (remission and persistence of UHR versus conversion). RESULTS: At one-year follow-up, 20% of patients had developed schizophrenia, 25.7% had remitted from their UHR status that, consequently, had persisted in 54.3%. No patient had fully remitted from mental disorders, even if UHR status was not maintained. Conversion was best predicted by any transient psychotic symptom and a disorganized communication score. No prediction model for outcome beyond conversion was identified. CONCLUSIONS: Our findings provide the first evidence for the predictive utility of UHR criteria in CAD in terms of brief intermittent psychotic symptoms (BIPS) when accompanied by signs of cognitive impairment, i.e. disorganized communication. However, because attenuated psychotic symptoms (APS) related to thought content and perception were indicative of non-conversion at 1-year follow-up, their use in early detection of psychosis in CAD needs further study. Overall, the need for more in-depth studies into developmental peculiarities in the early detection and treatment of psychoses with an onset of illness in childhood and early adolescence was further highlighted.
Authors: Jordina Tor; Montserrat Dolz; Anna Sintes; Daniel Muñoz; Marta Pardo; Elena de la Serna; Olga Puig; Gisela Sugranyes; Inmaculada Baeza Journal: Eur Child Adolesc Psychiatry Date: 2017-09-15 Impact factor: 4.785
Authors: Arsime Demjaha; Sara Weinstein; Daniel Stahl; Fern Day; Lucia Valmaggia; Grazia Rutigliano; Andrea De Micheli; Paolo Fusar-Poli; Philip McGuire Journal: BJPsych Open Date: 2017-07-14
Authors: Marco Armando; Maude Schneider; Maria Pontillo; Stefano Vicari; Martin Debbané; Frauke Schultze-Lutter; Stephan Eliez Journal: PLoS One Date: 2017-04-13 Impact factor: 3.240
Authors: Aaltsje Malda; Nynke Boonstra; Hans Barf; Steven de Jong; Andre Aleman; Jean Addington; Marita Pruessner; Dorien Nieman; Lieuwe de Haan; Anthony Morrison; Anita Riecher-Rössler; Erich Studerus; Stephan Ruhrmann; Frauke Schultze-Lutter; Suk Kyoon An; Shinsuke Koike; Kiyoto Kasai; Barnaby Nelson; Patrick McGorry; Stephen Wood; Ashleigh Lin; Alison Y Yung; Magdalena Kotlicka-Antczak; Marco Armando; Stefano Vicari; Masahiro Katsura; Kazunori Matsumoto; Sarah Durston; Tim Ziermans; Lex Wunderink; Helga Ising; Mark van der Gaag; Paolo Fusar-Poli; Gerdina Hendrika Maria Pijnenborg Journal: Front Psychiatry Date: 2019-05-21 Impact factor: 4.157
Authors: Ji Chen; Tobias Wensing; Felix Hoffstaedter; Edna C Cieslik; Veronika I Müller; Kaustubh R Patil; André Aleman; Birgit Derntl; Oliver Gruber; Renaud Jardri; Lydia Kogler; Iris E Sommer; Simon B Eickhoff; Thomas Nickl-Jockschat Journal: Neuroimage Clin Date: 2021-04-30 Impact factor: 4.881
Authors: Gonzalo Salazar de Pablo; Livia Soardo; Anna Cabras; Joana Pereira; Simi Kaur; Filippo Besana; Vincenzo Arienti; Francesco Coronelli; Jae Il Shin; Marco Solmi; Natalia Petros; Andre F Carvalho; Philip McGuire; Paolo Fusar-Poli Journal: Epidemiol Psychiatr Sci Date: 2022-01-19 Impact factor: 6.892