Literature DB >> 26526493

Natural polyphenols based new therapeutic avenues for advanced biomedical applications.

Megha Agrawal1.   

Abstract

Polyphenols are naturally occurring, synthetic or semisynthetic organic compounds that offer a vast array of advanced biomedical applications. The mostly researched polyphenolic compounds are resveratrol and flavanols, notably (-)-epicatechin. The ongoing research on clinically important resveratrol and flavanols has revealed their potentials as extremely efficient drug agents that can be leveraged for new therapeutic designs for combating stroke related injuries, cancer and renal failures. Here, we have highlighted recent developments in this area with an emphasis on the biomedical applications of polyphenols. Also, a perspective on the future research directions has been discussed. We believe that this review would facilitate further research and development of polyphenols as a therapeutic avenue in medical science.

Entities:  

Keywords:  Antioxidant; cancer; epicatechin; resveratrol; stroke

Mesh:

Substances:

Year:  2015        PMID: 26526493     DOI: 10.3109/03602532.2015.1102933

Source DB:  PubMed          Journal:  Drug Metab Rev        ISSN: 0360-2532            Impact factor:   4.518


  5 in total

1.  Transformed Root Extract of Leonurus sibiricus Induces Apoptosis through Intrinsic and Extrinsic Pathways in Various Grades of Human Glioma Cells.

Authors:  Przemysław Sitarek; Ewa Skała; Monika Toma; Marzena Wielanek; Janusz Szemraj; Tomasz Skorski; Adam J Białas; Tomasz Sakowicz; Tomasz Kowalczyk; Maciej Radek; Halina Wysokińska; Tomasz Śliwiński
Journal:  Pathol Oncol Res       Date:  2016-12-28       Impact factor: 3.201

2.  Majoon ushba, a polyherbal compound, suppresses pro-inflammatory mediators and RANKL expression via modulating NFкB and MAPKs signaling pathways in fibroblast-like synoviocytes from adjuvant-induced arthritic rats.

Authors:  Ramamoorthi Ganesan; Hari Madhuri Doss; Mahaboobkhan Rasool
Journal:  Immunol Res       Date:  2016-08       Impact factor: 2.829

3.  Geraniin Inhibits LPS-Induced THP-1 Macrophages Switching to M1 Phenotype via SOCS1/NF-κB Pathway.

Authors:  Xinxin Liu; Ji Li; Xiaohong Peng; Bo Lv; Peng Wang; Xiaoming Zhao; Bo Yu
Journal:  Inflammation       Date:  2016-08       Impact factor: 4.092

4.  Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae.

Authors:  Begoña Euba; Nahikari López-López; Irene Rodríguez-Arce; Ariadna Fernández-Calvet; Montserrat Barberán; Nuria Caturla; Sara Martí; Roberto Díez-Martínez; Junkal Garmendia
Journal:  Sci Rep       Date:  2017-10-16       Impact factor: 4.379

5.  Comparison of the main components and bioactivity of Rhus verniciflua Stokes extracts by different detoxification processing methods.

Authors:  Seon-Ok Lee; Sung-Ji Kim; Ju-Sung Kim; Hyuk Ji; Eun-Ok Lee; Hyo-Jeong Lee
Journal:  BMC Complement Altern Med       Date:  2018-08-30       Impact factor: 3.659

  5 in total

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