Leanne R De Souza1, Howard Berger2, Ravi Retnakaran3, Jonathon L Maguire4, Avery B Nathens5, Philip W Connelly4, Joel G Ray6. 1. Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada. 2. Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, ON, Canada Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada. 3. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada Department of Medicine, University of Toronto, Toronto, ON, Canada. 4. Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada. 5. Institute of Medical Science, University of Toronto, Toronto, ON, Canada Department of Surgery, Sunnybrook Health Sciences Center, Toronto, ON, Canada. 6. Department of Obstetrics and Gynecology, St. Michael's Hospital, Toronto, ON, Canada Institute of Medical Science, University of Toronto, Toronto, ON, Canada Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, Canada Department of Medicine, University of Toronto, Toronto, ON, Canada rayj@smh.ca.
Abstract
OBJECTIVE: This study assessed the association between first-trimester abdominal adiposity and dysglycemia and gestational diabetes mellitus (GDM) in midpregnancy. RESEARCH DESIGN AND METHODS: In a prospective cohort of 485 women, we measured subcutaneous (SAT), visceral (VAT), and total (TAT) adipose tissue depth, using ultrasound at 11-14 weeks' gestation. Logistic regression analysis assessed the relation between quartiles of SAT, VAT, or TAT depth and the composite outcome of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or GDM, based on a 75-g oral glucose tolerance test at 24-28 weeks. RESULTS: Adjusting for maternal age, ethnicity, family history of diabetes, and BMI, quartile 4 versus quartile 1 VAT (adjusted odds ratio [aOR] 3.1, 95% CI 1.1-9.5) and TAT (aOR 2.7, 95% CI 1.1-7.8) were significantly associated with the composite outcome, but SAT was not (aOR 1.8, 95% CI 0.70-4.8). The same was seen for GDM alone. CONCLUSIONS: Elevated first-trimester VAT and TAT depth independently predicted the risk of dysglycemia later in pregnancy.
OBJECTIVE: This study assessed the association between first-trimester abdominal adiposity and dysglycemia and gestational diabetes mellitus (GDM) in midpregnancy. RESEARCH DESIGN AND METHODS: In a prospective cohort of 485 women, we measured subcutaneous (SAT), visceral (VAT), and total (TAT) adipose tissue depth, using ultrasound at 11-14 weeks' gestation. Logistic regression analysis assessed the relation between quartiles of SAT, VAT, or TAT depth and the composite outcome of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or GDM, based on a 75-g oral glucose tolerance test at 24-28 weeks. RESULTS: Adjusting for maternal age, ethnicity, family history of diabetes, and BMI, quartile 4 versus quartile 1 VAT (adjusted odds ratio [aOR] 3.1, 95% CI 1.1-9.5) and TAT (aOR 2.7, 95% CI 1.1-7.8) were significantly associated with the composite outcome, but SAT was not (aOR 1.8, 95% CI 0.70-4.8). The same was seen for GDM alone. CONCLUSIONS: Elevated first-trimester VAT and TAT depth independently predicted the risk of dysglycemia later in pregnancy.
Authors: Teresa Janevic; Jennifer Zeitlin; Natalia Egorova; Amy Balbierz; Elizabeth A Howell Journal: Ann Epidemiol Date: 2018-02-15 Impact factor: 3.797
Authors: Eric K Broni; Chiadi E Ndumele; Justin B Echouffo-Tcheugui; Rita R Kalyani; Wendy L Bennett; Erin D Michos Journal: Curr Diab Rep Date: 2022-02-14 Impact factor: 4.810
Authors: L R De Souza; H Berger; R Retnakaran; P A Vlachou; J L Maguire; A B Nathens; P W Connelly; J G Ray Journal: Nutr Diabetes Date: 2016-09-19 Impact factor: 5.097