Lisa Ceglia1,2, Jason Nelson3, James Ware4, Konstantinos-Dionysios Alysandratos5, George A Bray6, Cheryl Garganta7, David M Nathan8, Frank B Hu9,10, Bess Dawson-Hughes11,12, Anastassios G Pittas11. 1. Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Box 268, 800, Washington Street, #268, Boston, MA, 02111, USA. lisa.ceglia@tufts.edu. 2. Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA. lisa.ceglia@tufts.edu. 3. Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA. 4. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA. 5. Division of Neurology, Boston University Medical Center, Boston, MA, USA. 6. Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA. 7. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainsville, FL, USA. 8. Diabetes Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. 9. Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA. 10. Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA. 11. Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Box 268, 800, Washington Street, #268, Boston, MA, 02111, USA. 12. Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Abstract
OBJECTIVE: We examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations. METHODS: The study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of theDiabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1. RESULTS: In cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % [95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (p < 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight. CONCLUSION: Our study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive.
RCT Entities:
OBJECTIVE: We examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations. METHODS: The study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1. RESULTS: In cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % [95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (p < 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight. CONCLUSION: Our study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive.
Entities:
Keywords:
Adipose tissue; Body composition; Body weight; Diabetes Prevention Program; Obesity; Vitamin D
Authors: Elizabeth J Mayer-Davis; Karen C Sparks; Katherine Hirst; Tina Costacou; Jennifer C Lovejoy; Judith G Regensteiner; Mary A Hoskin; Andrea M Kriska; George A Bray Journal: Ann Epidemiol Date: 2004-11 Impact factor: 3.797
Authors: Jia Li; Mary E Byrne; Eugene Chang; Yan Jiang; Shawn S Donkin; Kimberly K Buhman; John R Burgess; Dorothy Teegarden Journal: J Steroid Biochem Mol Biol Date: 2008-09-17 Impact factor: 4.292
Authors: Anne C Looker; Christine M Pfeiffer; David A Lacher; Rosemary L Schleicher; Mary Frances Picciano; Elizabeth A Yetley Journal: Am J Clin Nutr Date: 2008-12 Impact factor: 7.045
Authors: Kendra A Young; Corinne D Engelman; Carl D Langefeld; Kristen G Hairston; Steven M Haffner; Michael Bryer-Ash; Jill M Norris Journal: J Clin Endocrinol Metab Date: 2009-06-23 Impact factor: 5.958
Authors: Alejandro Santos; Teresa F Amaral; Rita S Guerra; Ana S Sousa; Luisa Álvares; Pedro Moreira; Patrícia Padrão; Cláudia Afonso; Nuno Borges Journal: BMJ Open Date: 2017-06-22 Impact factor: 2.692