Gustavo P Avegliano1, Juan P Costabel1, Federico M Asch2, Agustina Sciancalepore1, Paola Kuschnir1, Marina Huguet3, Catalina Tobon-Gomez3, Alejandro F Frangi4, Ricardo Ronderos1. 1. Department of Cardiovascular Imaging, Cardiovascular Institute of Buenos Aires, Buenos Aires, Argentina. 2. Medstar Health Research Institute at Washington Hospital Center and Georgetown University, Washington, District of Columbia. 3. CETIR-Pilar-Sant Jordi Clinic, Barcelona, Spain. 4. Center for Computational Imaging (Simulation Technologies in Biomedicine) (CISTIB), The University of Sheffield, Sheffield, United Kingdom.
Abstract
INTRODUCTION AND OBJECTIVES: Patients with hypertrophic cardiomyopathy (HCM) have irregular ventricular shapes with small and sometimes obliterated cavities at end-systole that affect the quantification of left ventricular mass (LVM) by conventional methods, such as M-mode or two-dimensional echocardiography. The goal of this study was to validate the use of real time three-dimensional echocardiography (RT3DE) to quantify LVM using cardiac magnetic resonance imaging (CMR) as a reference, in a large population of patients with different types of HCM. METHODS: Forty-eight consecutive patients with HCM had a complete transthoracic examination and CMR performed within 7 days. LVM was calculated by M-mode and RT3DE and compared to CMR that served as gold standard. RESULTS: Left ventricular mass calculated by RT3DE was 195 ± 41 g and 187 ± 49 g by CMR. The correlation between the two methods was moderate, with a Lin index of 0.63 and good linear correlation (r = 0.63, P < 0.0001). The correlation was high when RT3DE was of high or adequate image quality. The correlation between LVM by M-mode and CMR was poor. CONCLUSION: Three-dimensional echocardiography is an accurate method for the quantification of LVM in patients with different subtypes of HCM that is in better agreement with CMR reference values than M-mode measurements.
INTRODUCTION AND OBJECTIVES:Patients with hypertrophic cardiomyopathy (HCM) have irregular ventricular shapes with small and sometimes obliterated cavities at end-systole that affect the quantification of left ventricular mass (LVM) by conventional methods, such as M-mode or two-dimensional echocardiography. The goal of this study was to validate the use of real time three-dimensional echocardiography (RT3DE) to quantify LVM using cardiac magnetic resonance imaging (CMR) as a reference, in a large population of patients with different types of HCM. METHODS: Forty-eight consecutive patients with HCM had a complete transthoracic examination and CMR performed within 7 days. LVM was calculated by M-mode and RT3DE and compared to CMR that served as gold standard. RESULTS: Left ventricular mass calculated by RT3DE was 195 ± 41 g and 187 ± 49 g by CMR. The correlation between the two methods was moderate, with a Lin index of 0.63 and good linear correlation (r = 0.63, P < 0.0001). The correlation was high when RT3DE was of high or adequate image quality. The correlation between LVM by M-mode and CMR was poor. CONCLUSION: Three-dimensional echocardiography is an accurate method for the quantification of LVM in patients with different subtypes of HCM that is in better agreement with CMR reference values than M-mode measurements.
Authors: Maria Angela Losi; Massimo Imbriaco; Grazia Canciello; Filomena Pacelli; Carlo Di Nardo; Raffaella Lombardi; Raffaele Izzo; Costantino Mancusi; Andrea Ponsiglione; Serena Dell'Aversana; Alberto Cuocolo; Giovanni de Simone; Bruno Trimarco; Emanuele Barbato Journal: J Cardiovasc Transl Res Date: 2019-09-05 Impact factor: 4.132
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