Joel G Ray1, Karyn E Medcalf2, Alison L Park3. 1. Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada2Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada 3Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. 2. School of Medicine, University of Toronto, Toronto, Ontario, Canada. 3. Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.