Literature DB >> 26523776

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors.

Linda J Valentijn1, Jan Koster1, Danny A Zwijnenburg1, Nancy E Hasselt1, Peter van Sluis1, Richard Volckmann1, Max M van Noesel2, Rani E George3,4, Godelieve A M Tytgat2,5, Jan J Molenaar1, Rogier Versteeg1.   

Abstract

Whole-genome sequencing detected structural rearrangements of TERT in 17 of 75 high-stage neuroblastomas, with five cases resulting from chromothripsis. Rearrangements were associated with increased TERT expression and targeted regions immediately up- and downstream of TERT, positioning a super-enhancer close to the breakpoints in seven cases. TERT rearrangements (23%), ATRX deletions (11%) and MYCN amplifications (37%) identify three almost non-overlapping groups of high-stage neuroblastoma, each associated with very poor prognosis.

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Year:  2015        PMID： 26523776     DOI： 10.1038/ng.3438

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  16 in total

1.  The somatic genomic landscape of chromophobe renal cell carcinoma.

Authors:  Caleb F Davis; Christopher J Ricketts; Min Wang; Lixing Yang; Andrew D Cherniack; Hui Shen; Christian Buhay; Hyojin Kang; Sang Cheol Kim; Catherine C Fahey; Kathryn E Hacker; Gyan Bhanot; Dmitry A Gordenin; Andy Chu; Preethi H Gunaratne; Michael Biehl; Sahil Seth; Benny A Kaipparettu; Christopher A Bristow; Lawrence A Donehower; Eric M Wallen; Angela B Smith; Satish K Tickoo; Pheroze Tamboli; Victor Reuter; Laura S Schmidt; James J Hsieh; Toni K Choueiri; A Ari Hakimi; Lynda Chin; Matthew Meyerson; Raju Kucherlapati; Woong-Yang Park; A Gordon Robertson; Peter W Laird; Elizabeth P Henske; David J Kwiatkowski; Peter J Park; Margaret Morgan; Brian Shuch; Donna Muzny; David A Wheeler; W Marston Linehan; Richard A Gibbs; W Kimryn Rathmell; Chad J Creighton
Journal:  Cancer Cell       Date:  2014-08-21       Impact factor: 31.743

2.  Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma.

Authors:  Sven Lindner; Hagen S Bachmann; Andrea Odersky; Simon Schaefers; Ludger Klein-Hitpass; Barbara Hero; Matthias Fischer; Angelika Eggert; Alexander Schramm; Johannes H Schulte
Journal:  Biomed Rep       Date:  2015-05-13

3.  Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.

Authors:  Robert J A Bell; H Tomas Rube; Alex Kreig; Andrew Mancini; Shaun D Fouse; Raman P Nagarajan; Serah Choi; Chibo Hong; Daniel He; Melike Pekmezci; John K Wiencke; Margaret R Wrensch; Susan M Chang; Kyle M Walsh; Sua Myong; Jun S Song; Joseph F Costello
Journal:  Science       Date:  2015-05-14       Impact factor: 47.728

4.  Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes.

Authors:  Jan J Molenaar; Jan Koster; Danny A Zwijnenburg; Peter van Sluis; Linda J Valentijn; Ida van der Ploeg; Mohamed Hamdi; Johan van Nes; Bart A Westerman; Jennemiek van Arkel; Marli E Ebus; Franciska Haneveld; Arjan Lakeman; Linda Schild; Piet Molenaar; Peter Stroeken; Max M van Noesel; Ingrid Ora; Evan E Santo; Huib N Caron; Ellen M Westerhout; Rogier Versteeg
Journal:  Nature       Date:  2012-02-22       Impact factor: 49.962

5.  Altered telomeres in tumors with ATRX and DAXX mutations.

Authors:  Christopher M Heaphy; Roeland F de Wilde; Yuchen Jiao; Alison P Klein; Barish H Edil; Chanjuan Shi; Chetan Bettegowda; Fausto J Rodriguez; Charles G Eberhart; Sachidanand Hebbar; G Johan Offerhaus; Roger McLendon; B Ahmed Rasheed; Yiping He; Hai Yan; Darell D Bigner; Sueli Mieko Oba-Shinjo; Suely Kazue Nagahashi Marie; Gregory J Riggins; Kenneth W Kinzler; Bert Vogelstein; Ralph H Hruban; Anirban Maitra; Nickolas Papadopoulos; Alan K Meeker
Journal:  Science       Date:  2011-06-30       Impact factor: 47.728

6.  Association of age at diagnosis and genetic mutations in patients with neuroblastoma.

Authors:  Nai-Kong V Cheung; Jinghui Zhang; Charles Lu; Matthew Parker; Armita Bahrami; Satish K Tickoo; Adriana Heguy; Alberto S Pappo; Sara Federico; James Dalton; Irene Y Cheung; Li Ding; Robert Fulton; Jianmin Wang; Xiang Chen; Jared Becksfort; Jianrong Wu; Catherine A Billups; David Ellison; Elaine R Mardis; Richard K Wilson; James R Downing; Michael A Dyer
Journal:  JAMA       Date:  2012-03-14       Impact factor: 56.272

7.  CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

Authors:  Edmond Chipumuro; Eugenio Marco; Camilla L Christensen; Nicholas Kwiatkowski; Tinghu Zhang; Clark M Hatheway; Brian J Abraham; Bandana Sharma; Caleb Yeung; Abigail Altabef; Antonio Perez-Atayde; Kwok-Kin Wong; Guo-Cheng Yuan; Nathanael S Gray; Richard A Young; Rani E George
Journal:  Cell       Date:  2014-11-06       Impact factor: 41.582

8.  Rearrangement of upstream sequences of the hTERT gene during cellular immortalization.

Authors:  Yuanjun Zhao; Shuwen Wang; Evgenya Y Popova; Sergei A Grigoryev; Jiyue Zhu
Journal:  Genes Chromosomes Cancer       Date:  2009-11       Impact factor: 5.006

9.  The genetic landscape of high-risk neuroblastoma.

Authors:  Trevor J Pugh; Olena Morozova; Edward F Attiyeh; Shahab Asgharzadeh; Jun S Wei; Daniel Auclair; Scott L Carter; Kristian Cibulskis; Megan Hanna; Adam Kiezun; Jaegil Kim; Michael S Lawrence; Lee Lichenstein; Aaron McKenna; Chandra Sekhar Pedamallu; Alex H Ramos; Erica Shefler; Andrey Sivachenko; Carrie Sougnez; Chip Stewart; Adrian Ally; Inanc Birol; Readman Chiu; Richard D Corbett; Martin Hirst; Shaun D Jackman; Baljit Kamoh; Alireza Hadj Khodabakshi; Martin Krzywinski; Allan Lo; Richard A Moore; Karen L Mungall; Jenny Qian; Angela Tam; Nina Thiessen; Yongjun Zhao; Kristina A Cole; Maura Diamond; Sharon J Diskin; Yael P Mosse; Andrew C Wood; Lingyun Ji; Richard Sposto; Thomas Badgett; Wendy B London; Yvonne Moyer; Julie M Gastier-Foster; Malcolm A Smith; Jaime M Guidry Auvil; Daniela S Gerhard; Michael D Hogarty; Steven J M Jones; Eric S Lander; Stacey B Gabriel; Gad Getz; Robert C Seeger; Javed Khan; Marco A Marra; Matthew Meyerson; John M Maris
Journal:  Nat Genet       Date:  2013-01-20       Impact factor: 38.330

10.  Integrative analysis of 111 reference human epigenomes.

Authors:  Anshul Kundaje; Wouter Meuleman; Jason Ernst; Misha Bilenky; Angela Yen; Alireza Heravi-Moussavi; Pouya Kheradpour; Zhizhuo Zhang; Jianrong Wang; Michael J Ziller; Viren Amin; John W Whitaker; Matthew D Schultz; Lucas D Ward; Abhishek Sarkar; Gerald Quon; Richard S Sandstrom; Matthew L Eaton; Yi-Chieh Wu; Andreas R Pfenning; Xinchen Wang; Melina Claussnitzer; Yaping Liu; Cristian Coarfa; R Alan Harris; Noam Shoresh; Charles B Epstein; Elizabeta Gjoneska; Danny Leung; Wei Xie; R David Hawkins; Ryan Lister; Chibo Hong; Philippe Gascard; Andrew J Mungall; Richard Moore; Eric Chuah; Angela Tam; Theresa K Canfield; R Scott Hansen; Rajinder Kaul; Peter J Sabo; Mukul S Bansal; Annaick Carles; Jesse R Dixon; Kai-How Farh; Soheil Feizi; Rosa Karlic; Ah-Ram Kim; Ashwinikumar Kulkarni; Daofeng Li; Rebecca Lowdon; GiNell Elliott; Tim R Mercer; Shane J Neph; Vitor Onuchic; Paz Polak; Nisha Rajagopal; Pradipta Ray; Richard C Sallari; Kyle T Siebenthall; Nicholas A Sinnott-Armstrong; Michael Stevens; Robert E Thurman; Jie Wu; Bo Zhang; Xin Zhou; Arthur E Beaudet; Laurie A Boyer; Philip L De Jager; Peggy J Farnham; Susan J Fisher; David Haussler; Steven J M Jones; Wei Li; Marco A Marra; Michael T McManus; Shamil Sunyaev; James A Thomson; Thea D Tlsty; Li-Huei Tsai; Wei Wang; Robert A Waterland; Michael Q Zhang; Lisa H Chadwick; Bradley E Bernstein; Joseph F Costello; Joseph R Ecker; Martin Hirst; Alexander Meissner; Aleksandar Milosavljevic; Bing Ren; John A Stamatoyannopoulos; Ting Wang; Manolis Kellis
Journal:  Nature       Date:  2015-02-19       Impact factor: 69.504
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  123 in total

1.  Telomere maintenance is pivotal for high-risk neuroblastoma.

Authors:  Falk Hertwig; Martin Peifer; Matthias Fischer
Journal:  Cell Cycle       Date:  2015-12-10       Impact factor: 4.534

Review 2.  Super-Enhancer-Driven Transcriptional Dependencies in Cancer.

Authors:  Satyaki Sengupta; Rani E George
Journal:  Trends Cancer       Date:  2017-04-12

3.  Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.

Authors:  Amanda Balboni Iniguez; Gabriela Alexe; Emily Jue Wang; Giovanni Roti; Sarvagna Patel; Liying Chen; Samuel Kitara; Amy Conway; Amanda L Robichaud; Björn Stolte; Pratiti Bandopadhayay; Amy Goodale; Sasha Pantel; Yenarae Lee; Dorian M Cheff; Matthew D Hall; Rajarshi Guha; Mindy I Davis; Marie Menard; Nicole Nasholm; William A Weiss; Jun Qi; Rameen Beroukhim; Federica Piccioni; Cory Johannessen; Kimberly Stegmaier
Journal:  Cancer Cell       Date:  2018-12-10       Impact factor: 31.743

4.  CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1- mantle cell lymphoma.

Authors:  David Martín-Garcia; Alba Navarro; Rafael Valdés-Mas; Guillem Clot; Jesús Gutiérrez-Abril; Miriam Prieto; Inmaculada Ribera-Cortada; Renata Woroniecka; Grzegorz Rymkiewicz; Susanne Bens; Laurence de Leval; Andreas Rosenwald; Judith A Ferry; Eric D Hsi; Kai Fu; Jan Delabie; Dennis Weisenburger; Daphne de Jong; Fina Climent; Sheila J O'Connor; Steven H Swerdlow; David Torrents; Sergi Beltran; Blanca Espinet; Blanca González-Farré; Luis Veloza; Dolors Costa; Estella Matutes; Reiner Siebert; German Ott; Leticia Quintanilla-Martinez; Elaine S Jaffe; Carlos López-Otín; Itziar Salaverria; Xose S Puente; Elias Campo; Sílvia Beà
Journal:  Blood       Date:  2018-12-11       Impact factor: 22.113

Review 5.  Super-enhancer function and its application in cancer targeted therapy.

Authors:  Faqing Tang; Zongbei Yang; Yuan Tan; Yuejin Li
Journal:  NPJ Precis Oncol       Date:  2020-02-12

Review 6.  The clinical applications of The Cancer Genome Atlas project for bladder cancer.

Authors:  Chad J Creighton
Journal:  Expert Rev Anticancer Ther       Date:  2018-08-13       Impact factor: 4.512

7.  5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.

Authors:  Mark A Applebaum; Erin K Barr; Jason Karpus; Diana C West-Szymanski; Meritxell Oliva; Elizabeth A Sokol; Sheng Zhang; Zhou Zhang; Wei Zhang; Alexandre Chlenski; Helen R Salwen; Emma Wilkinson; Marija Dobratic; Robert L Grossman; Lucy A Godley; Barbara E Stranger; Chuan He; Susan L Cohn
Journal:  Clin Cancer Res       Date:  2019-12-18       Impact factor: 12.531

Review 8.  Telomeres in cancer: tumour suppression and genome instability.

Authors:  John Maciejowski; Titia de Lange
Journal:  Nat Rev Mol Cell Biol       Date:  2017-01-18       Impact factor: 94.444

9.  Nervous system: Embryonal tumors: Neuroblastoma.

Authors:  Caileigh Pudela; Skye Balyasny; Mark A Applebaum
Journal:  Atlas Genet Cytogenet Oncol Haematol       Date:  2020-07

10.  Telomere Maintenance Mechanisms Define Clinical Outcome in High-Risk Neuroblastoma.

Authors:  Balakrishna Koneru; Gonzalo Lopez; Ahsan Farooqi; Karina L Conkrite; Thinh H Nguyen; Shawn J Macha; Apexa Modi; Jo Lynne Rokita; Eduardo Urias; Ashly Hindle; Heather Davidson; Kristyn Mccoy; Jonas Nance; Vanda Yazdani; Meredith S Irwin; Shengping Yang; David A Wheeler; John M Maris; Sharon J Diskin; C Patrick Reynolds
Journal:  Cancer Res       Date:  2020-04-14       Impact factor: 12.701
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