Literature DB >> 26523773

Emerging therapeutic targets for the treatment of hepatic fibrosis.

Paolo Fagone1, Katia Mangano1, Antonio Pesce2, Teresa Rosanna Portale2, Stefano Puleo2, Ferdinando Nicoletti3.   

Abstract

Fibrosis represents a response to chronic injury, aimed at maintaining organ integrity. Hepatic fibrosis is mainly related to chronic viral hepatitis B or C (HBV or HCV), alcoholic and nonalcoholic steatohepatitis (NASH), and biliary diseases. A deep understanding of the cellular and molecular mechanisms underlying liver fibrosis has enabled the development of 'pathogenetic tailored' therapeutic interventions. However, effective drugs to prevent or revert hepatic fibrosis are still lacking. In this review, we discuss the cellular populations and the molecular pathways involved in liver fibrogenesis as well as the novel approaches currently being tested in clinical trials.
Copyright © 2015 Elsevier Ltd. All rights reserved.

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Year:  2015        PMID： 26523773     DOI： 10.1016/j.drudis.2015.10.015

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  28 in total

1.  Efficacy and safety of fermented garlic extract on hepatic function in adults with elevated serum gamma-glutamyl transpeptidase levels: a double-blind, randomized, placebo-controlled trial.

Authors:  Ha-Na Kim; Sung-Goo Kang; Yong Kyun Roh; Min-Kyu Choi; Sang-Wook Song
Journal:  Eur J Nutr       Date:  2016-10-14       Impact factor: 5.614

2.  IGFBP-6/sonic hedgehog/TLR4 signalling axis drives bone marrow fibrotic transformation in primary myelofibrosis.

Authors:  Lucia Longhitano; Daniele Tibullo; Nunzio Vicario; Cesarina Giallongo; Enrico La Spina; Alessandra Romano; Sofia Lombardo; Marina Moretti; Francesco Masia; Anna Rita Daniela Coda; Santina Venuto; Paolo Fontana; Rosalba Parenti; Giovanni Li Volti; Michelino Di Rosa; Giuseppe A Palumbo; Arcangelo Liso
Journal:  Aging (Albany NY)       Date:  2021-12-14       Impact factor: 5.682

3.  Rubus chingii Hu. unripe fruits extract ameliorates carbon tetrachloride-induced liver fibrosis and improves the associated gut microbiota imbalance.

Authors:  Jianjun Wu; Dingqi Zhang; Bo Zhu; Siqi Wang; Yongbin Xu; Congcong Zhang; Hailing Yang; Shunchun Wang; Ping Liu; Luping Qin; Wei Liu
Journal:  Chin Med       Date:  2022-05-12       Impact factor: 4.546

4.  Predictors for advanced liver fibrosis in chronic hepatitis B virus infection with persistently normal or mildly elevated alanine aminotransferase.

Authors:  Dexin Wang; Ping Zhang; Min Zhang
Journal:  Exp Ther Med       Date:  2017-09-29       Impact factor: 2.447

5.  Effects of Enzymatically Depolymerized Low Molecular Weight Heparins on CCl4-Induced Liver Fibrosis.

Authors:  Yishu Yan; Changge Guan; Shanshan Du; Wenming Zhu; Yang Ji; Nan Su; Xiang Mei; Dong He; Yuan Lu; Chong Zhang; Xin-Hui Xing
Journal:  Front Pharmacol       Date:  2017-08-21       Impact factor: 5.810

6.  Comprehensive Study of Multiple Stages Progressing to Nonalcoholic Steatohepatitis with Subsequent Fibrosis in SD Rats.

Authors:  Lulu Wang; Susu Wu; Minxuan Cai; Ji Ma; Shengcun Li; Maoru Li; Yan Xu; Lixin Wei; Jing Shang
Journal:  Int J Mol Sci       Date:  2017-08-18       Impact factor: 5.923

7.  The Active Components of Fuzheng Huayu Formula and Their Potential Mechanism of Action in Inhibiting the Hepatic Stellate Cells Viability - A Network Pharmacology and Transcriptomics Approach.

Authors:  Xinrui Xing; Si Chen; Ling Li; Yan Cao; Langdong Chen; Xiaobo Wang; Zhenyu Zhu
Journal:  Front Pharmacol       Date:  2018-05-24       Impact factor: 5.810

Review 8.  Current and Emerging Approaches for Hepatic Fibrosis Treatment.

Authors:  Jingguo Li; Biguang Tuo
Journal:  Gastroenterol Res Pract       Date:  2021-07-16       Impact factor: 2.260

9.  MicroRNA-145 Increases the Apoptosis of Activated Hepatic Stellate Cells Induced by TRAIL through NF-κB Signaling Pathway.

Authors:  Junfa Yang; Qingxue Liu; Shiyang Cao; Tao Xu; Xiaofeng Li; Dandan Zhou; Linxin Pan; Changyao Li; Cheng Huang; Xiaoming Meng; Lei Zhang; Xiao Wang
Journal:  Front Pharmacol       Date:  2018-01-12       Impact factor: 5.810

Review 10.  Extracellular Vesicles as Carriers of Non-coding RNAs in Liver Diseases.

Authors:  Junfa Yang; Changyao Li; Lei Zhang; Xiao Wang
Journal:  Front Pharmacol       Date:  2018-04-24       Impact factor: 5.810
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