María Esther Castillo1, Carlos Bada2, Olguita Del Aguila3, Verónica Petrozzi-Helasvuo4, Verónica Casabona-Ore4, Isabel Reyes2, Juana Del Valle-Mendoza5. 1. Instituto Nacional de Salud del Niño, Breña, Lima, Peru. 2. Hospital de Emergencias Pediátricas, La Victoria, Lima, Peru. 3. Hospital Edgardo Rebagliati Martins, Jr, Jesús María, Lima, Peru. 4. Centro de Investigación de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cuadra 2, Chorrillos, Lima, Peru. 5. Centro de Investigación de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cuadra 2, Chorrillos, Lima, Peru. Electronic address: jdelvall@upc.edu.pe.
Abstract
OBJECTIVES: To report the incidence, epidemiology, and clinical features of Bordetella pertussis in Peruvian infants under 1 year old. PATIENTS AND METHODS: A prospective cross-sectional study was conducted in five hospitals in Peru from January 2010 to July 2012. A total of 392 infants under 1 year old were admitted with a clinical diagnosis of whooping cough and tested for B. pertussis by PCR. RESULTS: The pertussis toxin and IS481 genes were detected in 39.54% (155/392) of the cases. Infants aged less than 3 months were the most affected, with a prevalence of 73.55% (114/155). The most common household contact was the mother, identified in 20% (31/155) of cases. Paroxysm of coughing (89.03%, 138/155), cyanosis (68.39%, 106/155), respiratory distress (67.09%, 104/155), and breastfeeding difficulties (39.35%, 61/155) were the most frequent symptoms reported. CONCLUSION: An increase in pertussis cases has been reported in recent years in Peru, despite national immunization efforts. Surveillance with PCR for B. pertussis is essential, especially in infants less than 1 year old, in whom a higher rate of disease-related complications and higher mortality have been reported.
OBJECTIVES: To report the incidence, epidemiology, and clinical features of Bordetella pertussis in Peruvian infants under 1 year old. PATIENTS AND METHODS: A prospective cross-sectional study was conducted in five hospitals in Peru from January 2010 to July 2012. A total of 392 infants under 1 year old were admitted with a clinical diagnosis of whooping cough and tested for B. pertussis by PCR. RESULTS: The pertussis toxin and IS481 genes were detected in 39.54% (155/392) of the cases. Infants aged less than 3 months were the most affected, with a prevalence of 73.55% (114/155). The most common household contact was the mother, identified in 20% (31/155) of cases. Paroxysm of coughing (89.03%, 138/155), cyanosis (68.39%, 106/155), respiratory distress (67.09%, 104/155), and breastfeeding difficulties (39.35%, 61/155) were the most frequent symptoms reported. CONCLUSION: An increase in pertussis cases has been reported in recent years in Peru, despite national immunization efforts. Surveillance with PCR for B. pertussis is essential, especially in infants less than 1 year old, in whom a higher rate of disease-related complications and higher mortality have been reported.
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Authors: Juana Del Valle-Mendoza; Wilmer Silva-Caso; Miguel Angel Aguilar-Luis; Cristina Del Valle-Vargas; Erico Cieza-Mora; Johanna Martins-Luna; Ronald Aquino-Ortega; Andrea Silva-Vásquez; Jorge Bazán-Mayra; Pablo Weilg Journal: BMC Res Notes Date: 2018-05-18
Authors: Laura Iglesias; Antonio Casabella Pernas; Melisa Hernández Febles; Elena Colino Gil; Alicia Eisman Maraver; María José Pena López Journal: An Pediatr (Engl Ed) Date: 2018-07-21