| Literature DB >> 26522949 |
Min Zhao1, Tomonori Kamada1, Aya Takeuchi1, Hiromi Nishioka1, Teruo Kuroda1, Yasuo Takeuchi2.
Abstract
Indolo[3,2-b]quinoline analogs (3a-3s), 4-(acridin-9-ylamino) phenol hydrochloride (4), benzofuro[3,2-b]quinoline (3t), indeno[1,2-b]quinolines (3u and 3v) have been synthesized. Those compounds were found to exhibit anti-bacterial activity towards Methicillin-resistant Staphylococcus aureus (anti-MRSA activity). Structure-activity relationship studies were conducted that indoloquinoline ring, benzofuroquinoline ring and 4-aminophenol group are essential structure for anti-MRSA activity.Entities:
Keywords: Anti-MRSA; Benzofuroquinoline; Indenoquinoline; Indoloquinoline; Structure–activity
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Year: 2015 PMID： 26522949 DOI： 10.1016/j.bmcl.2015.10.058
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823