Lisa M Brindley1, Loes Koelewijn2, Amanda Kirby3, Natalie Williams3, Marie Thomas3, Johann Te Water-Naudé4, Frances Gibbon4, Suresh Muthukumaraswamy5, Krish D Singh2, Khalid Hamandi6. 1. Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK. Electronic address: lisabrindley78@gmail.com. 2. Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK. 3. Dyscovery Centre, University of South Wales, Newport, UK. 4. Department of Child Health, University Hospital of Wales, Cardiff, UK. 5. Schools of Pharmacy and Psychology, University of Auckland, Auckland, New Zealand. 6. Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK; Welsh Epilepsy Centre, University Hospital of Wales, Cardiff, UK.
Abstract
OBJECTIVE: Magnetoencephalography (MEG) and a simple motor paradigm were used to study induced sensorimotor responses and their relationship to motor skills in children diagnosed with Benign Epilepsy with Centro-Temporal Spikes (BECTS). METHODS: Twenty-one children with BECTS and 15 age-matched controls completed a finger abduction task in MEG; movement-related oscillatory responses were derived and contrasted between groups. A subset of children also completed psycho-behavioural assessments. Regression analyses explored the relationship of MEG responses to manual dexterity performance, and dependence upon clinical characteristics. RESULTS: In children with BECTS, manual dexterity was below the population mean (p=.002) and three showed severe impairment. Our main significant finding was of reduced ipsilateral movement related beta desynchrony (MRBDi) in BECTS relative to the control group (p=.03) and predicted by epileptic seizure recency (p=.02), but not age, medication status, or duration of epilepsy. Laterality scores across the entire cohort indicated that less lateralised MRBD predicted better manual dexterity (p=.04). CONCLUSIONS: Altered movement-related oscillatory responses in ipsilateral motor cortex were associated with motor skill deficits in children with BECTS. These changes were more marked in those with more recent seizures. SIGNIFICANCE: These findings may reflect differences in inter-hemispheric interactions during motor control in BECTS.
OBJECTIVE: Magnetoencephalography (MEG) and a simple motor paradigm were used to study induced sensorimotor responses and their relationship to motor skills in children diagnosed with Benign Epilepsy with Centro-Temporal Spikes (BECTS). METHODS: Twenty-one children with BECTS and 15 age-matched controls completed a finger abduction task in MEG; movement-related oscillatory responses were derived and contrasted between groups. A subset of children also completed psycho-behavioural assessments. Regression analyses explored the relationship of MEG responses to manual dexterity performance, and dependence upon clinical characteristics. RESULTS: In children with BECTS, manual dexterity was below the population mean (p=.002) and three showed severe impairment. Our main significant finding was of reduced ipsilateral movement related beta desynchrony (MRBDi) in BECTS relative to the control group (p=.03) and predicted by epilepticseizure recency (p=.02), but not age, medication status, or duration of epilepsy. Laterality scores across the entire cohort indicated that less lateralised MRBD predicted better manual dexterity (p=.04). CONCLUSIONS: Altered movement-related oscillatory responses in ipsilateral motor cortex were associated with motor skill deficits in children with BECTS. These changes were more marked in those with more recent seizures. SIGNIFICANCE: These findings may reflect differences in inter-hemispheric interactions during motor control in BECTS.
Authors: Dan Y Song; Sally M Stoyell; Erin E Ross; Lauren M Ostrowski; Emily L Thorn; Steven M Stufflebeam; Amy K Morgan; Britt C Emerton; Mark A Kramer; Catherine J Chu Journal: Brain Behav Date: 2019-02-20 Impact factor: 2.708
Authors: Lauren M Ostrowski; Daniel Y Song; Emily L Thorn; Erin E Ross; Sally M Stoyell; Dhinakaran M Chinappen; Uri T Eden; Mark A Kramer; Britt C Emerton; Amy K Morgan; Steven M Stufflebeam; Catherine J Chu Journal: Brain Commun Date: 2019-06-19