Elizabeth M Cespedes1,2,3, Shilpa N Bhupathiraju4, Yanping Li4, Bernard Rosner5,6, Susan Redline7,8, Frank B Hu4,7. 1. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. emc611@mail.harvard.edu. 2. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. emc611@mail.harvard.edu. 3. Division of Research, Kaiser Permanente Northern California, 2000 Broadway, 5th Floor, Oakland, CA, 94612, USA. emc611@mail.harvard.edu. 4. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 5. Channing Division of Network Medicine, Harvard Medical School, Boston, MA, USA. 6. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 7. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 8. Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Abstract
AIMS/HYPOTHESIS: Baseline sleep duration has a U-shaped relationship with type 2 diabetes, but little research examines the associated changes. We examined long-term changes in sleep duration and concomitant changes in diet, physical activity, weight and subsequent diabetes. METHODS: The cohort includes 59,031 women aged 55-83 years in the Nurses' Health Study without diabetes in 2000. Change in sleep duration is the difference between self-reported 24 h sleep duration in 1986 and 2000. Diet, physical activity and covariates were updated every 2-4 years. Self-reported diabetes was confirmed via validated questionnaires. Cox regression models were adjusted for 1986 sleep duration and 1986 values of diabetes risk factors, including BMI, and subsequently for change in covariates from 1986 to 2000. RESULTS: We documented 3,513 incident diabetes cases through to 2012. Compared with no change, decreases in sleep duration were adversely associated with changes in diet quality and physical activity, while increases were associated with greater weight gain. After adjustment for 1986 covariates, HRs (95% CI) for ≤ -2, > -2 to < 0, > 0 to < 2 and ≥ 2 h/day changes in sleep duration (vs no change) were 1.09 (0.93, 1.28), 1.10 (1.001, 1.12), 1.09 (1.00, 1.18) and 1.30 (1.14, 1.46), respectively. Additional adjustment for diet and physical activity did not appreciably alter the results. Increases in sleep duration ≥ 2 h/day remained adversely associated with diabetes (HR [95% CI]: 1.15 [1.01, 1.30]) after adjustment for change in covariates, including BMI. CONCLUSIONS/ INTERPRETATION: Increases in sleep duration among middle-aged and older women were modestly associated with risk of diabetes; changes in diet, physical activity and BMI did not explain associations.
AIMS/HYPOTHESIS: Baseline sleep duration has a U-shaped relationship with type 2 diabetes, but little research examines the associated changes. We examined long-term changes in sleep duration and concomitant changes in diet, physical activity, weight and subsequent diabetes. METHODS: The cohort includes 59,031 women aged 55-83 years in the Nurses' Health Study without diabetes in 2000. Change in sleep duration is the difference between self-reported 24 h sleep duration in 1986 and 2000. Diet, physical activity and covariates were updated every 2-4 years. Self-reported diabetes was confirmed via validated questionnaires. Cox regression models were adjusted for 1986 sleep duration and 1986 values of diabetes risk factors, including BMI, and subsequently for change in covariates from 1986 to 2000. RESULTS: We documented 3,513 incident diabetes cases through to 2012. Compared with no change, decreases in sleep duration were adversely associated with changes in diet quality and physical activity, while increases were associated with greater weight gain. After adjustment for 1986 covariates, HRs (95% CI) for ≤ -2, > -2 to < 0, > 0 to < 2 and ≥ 2 h/day changes in sleep duration (vs no change) were 1.09 (0.93, 1.28), 1.10 (1.001, 1.12), 1.09 (1.00, 1.18) and 1.30 (1.14, 1.46), respectively. Additional adjustment for diet and physical activity did not appreciably alter the results. Increases in sleep duration ≥ 2 h/day remained adversely associated with diabetes (HR [95% CI]: 1.15 [1.01, 1.30]) after adjustment for change in covariates, including BMI. CONCLUSIONS/ INTERPRETATION: Increases in sleep duration among middle-aged and older women were modestly associated with risk of diabetes; changes in diet, physical activity and BMI did not explain associations.
Entities:
Keywords:
Body weight; Diabetes mellitus; Diet; Sleep
Authors: Shawn D Youngstedt; Girardin Jean-Louis; Richard R Bootzin; Daniel F Kripke; Jonnifer Cooper; Lauren R Dean; Fabio Catao; Shelli James; Caitlin Vining; Natasha J Williams; Michael R Irwin Journal: Contemp Clin Trials Date: 2013-06-28 Impact factor: 2.226
Authors: Sanjay R Patel; Najib T Ayas; Mark R Malhotra; David P White; Eva S Schernhammer; Frank E Speizer; Meir J Stampfer; Frank B Hu Journal: Sleep Date: 2004-05-01 Impact factor: 5.849
Authors: Marta Guasch-Ferré; Yanping Li; Shilpa N Bhupathiraju; Tianyi Huang; Jean-Philippe Drouin-Chartier; JoAnn E Manson; Qi Sun; Eric B Rimm; Kathryn M Rexrode; Walter C Willett; Meir J Stampfer; Frank B Hu Journal: Am J Prev Med Date: 2022-03-28 Impact factor: 6.604
Authors: Megu Y Baden; Frank B Hu; Celine Vetter; Eva Schernhammer; Susan Redline; Tianyi Huang Journal: Diabetes Care Date: 2020-03-24 Impact factor: 19.112
Authors: Kaitlyn M Berry; Aaron T Berger; Melissa N Laska; Darin J Erickson; Kathleen M Lenk; Conrad Iber; Kelsie M Full; Kyla Wahlstrom; Susan Redline; Rachel Widome Journal: Sleep Health Date: 2021-09-01