Literature DB >> 26521296

A hostel for the hostile: the bone marrow niche in hematologic neoplasms.

Daniela S Krause1, David T Scadden2.   

Abstract

Our understanding of the biology of the normal hematopoietic stem cell niche has increased steadily due to improved murine models and sophisticated imaging tools. Less well understood, but of growing interest, is the interaction between cells in the bone marrow during the initiation, maintenance and treatment of hematologic neoplasms. This review summarizes the emerging concepts of the normal and leukemic hematopoietic bone marrow niche. Furthermore, it reviews current models of how the microenvironment of the bone marrow may contribute to or be modified by leukemogenesis. Finally, it provides the rationale for a "two-pronged" approach, directly targeting cancer cells themselves while also targeting the bone microenvironment to make it inhospitable to malignant cells and, ultimately, eradicating cancer stem-like cells. Copyright© Ferrata Storti Foundation.

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Year:  2015        PMID： 26521296      PMCID： PMC4825315          DOI： 10.3324/haematol.2014.113852

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  129 in total

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  38 in total

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