Michaela C Pascoe1, Ingmar Skoog2, Christian Blomstrand3, Thomas Linden4. 1. Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 100, S-405 30 Gothenburg, Sweden. Electronic address: Michaela.pascoe@gmail.com. 2. Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 100, S-405 30 Gothenburg, Sweden. Electronic address: ingmar.skoog@gu.se. 3. Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 100, S-405 30 Gothenburg, Sweden. Electronic address: christian.blomstrand@gu.se. 4. Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 100, S-405 30 Gothenburg, Sweden; Florey Institute of Neuroscience and Mental Health, Melbourne-245 Burgundy Street, Heidelberg, Victoria 3084, Australia; Hunter Medical Research Institute, Newcastle-1 Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia. Electronic address: Thomas.Linden@neuro.gu.se.
Abstract
BACKGROUND/ OBJECTIVES: Post-stroke depression affects approximately one third of stroke survivors. In non-stroke affected populations, depressive symptomatology is associated with hypoalbuminemia. This is also common among stroke survivors and associated with poor outcome and increased mortality. The role of stroke-associated hypoalbuminemia in post-stroke depression is not clear. We aimed to explore the relationship between serum albumin and post-stroke depression, as measured 20 months post-stroke. SUBJECTS/ METHODS: Observational cohort study of elderly Swedish patients drawn from the 'Gothenburg 70+ Stroke Study' (n=149) and assessed at 20 months after stroke onset. Serum albumin was drawn from venous blood and analysed with gas chromatography/mass spectrometry. Depressive symptomatology was assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS) and functional impairment was assessed using the Barthel Index. RESULTS: Analysis of covariance analysis showed that serum albumin levels were associated with depressive symptoms at 20 months after stroke. Multivariate analysis of covariance showed that disability scores at 3 days were associated with depressive symptoms at 20 months after stroke and after accounting for the age covariate. Stroke survivors were not clinically deficient in serum albumin. CONCLUSIONS: Low serum albumin appears to be associated with depressive symptoms in elderly individuals long term post-stroke.
BACKGROUND/ OBJECTIVES: Post-stroke depression affects approximately one third of stroke survivors. In non-stroke affected populations, depressive symptomatology is associated with hypoalbuminemia. This is also common among stroke survivors and associated with poor outcome and increased mortality. The role of stroke-associated hypoalbuminemia in post-stroke depression is not clear. We aimed to explore the relationship between serum albumin and post-stroke depression, as measured 20 months post-stroke. SUBJECTS/ METHODS: Observational cohort study of elderly Swedish patients drawn from the 'Gothenburg 70+ Stroke Study' (n=149) and assessed at 20 months after stroke onset. Serum albumin was drawn from venous blood and analysed with gas chromatography/mass spectrometry. Depressive symptomatology was assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS) and functional impairment was assessed using the Barthel Index. RESULTS: Analysis of covariance analysis showed that serum albumin levels were associated with depressive symptoms at 20 months after stroke. Multivariate analysis of covariance showed that disability scores at 3 days were associated with depressive symptoms at 20 months after stroke and after accounting for the age covariate. Stroke survivors were not clinically deficient in serum albumin. CONCLUSIONS: Low serum albumin appears to be associated with depressive symptoms in elderly individuals long term post-stroke.
Authors: Daniel C McFarland; Allison J Applebaum; Erik Bengtsen; Yesne Alici; William Breitbart; Andrew H Miller; Christian Nelson Journal: Psychooncology Date: 2021-09-04 Impact factor: 3.955
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