P A Cascales-Campos1, P Ramírez2, V Lopez1, R Gonzalez1, L Saenz-Mateos1, E Llacer1, F Sánchez Bueno1, R Robles1, J A Pons3, A Capel4, L Frutos5, J L Navarro5, P Muñoz-Ramon1, P Parrilla1. 1. Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain. 2. Department of Surgery, Liver Transplant Unit, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain. Electronic address: ramirezp@um.es. 3. Department of Hepatology, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain. 4. Department of Radiology, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain. 5. Department of Nuclear Medicine, Hospital Clínico Universitario Virgen de la Arrixaca (Murcia)-IMIB Arrixaca, Murcia, Spain.
Abstract
INTRODUCTION: The aim of this study was to analyze the correlation between 18-FDG positron emission tomography (PET)/computed tomography (CT), histological necrosis, and prognosis after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) patients undergoing orthotopic liver transplantation (OLT). PATIENTS: From January 2007 through December 2013, 81 patients with HCC and liver cirrhosis were included in our liver transplantation program. For this study we selected patients who underwent 18-FDG PET/CT pre-TACE and post-TACE. All patients underwent liver transplantation within 8 weeks after PET/CT. RESULTS: Twenty patients with a median age of 58 years (range, 46-69 years) underwent an 18-FDG PET/CT before and after TACE. The median Standardized Uptake Value (SUV) before TACE was 3.8 (range, 2.6-8.7), with a median post-TACE SUV of 0% (range, 0-4). Among patients whose post-TACE SUV decreased to <3, >70% necrosis was observed upon study of a hepatectomy sample, with a survival rate of 100% and 80% at 1 and 3 years, respectively. CONCLUSION: In conclusion, performance of an 18-FDG PET/CT before and after TACE with comparison of SUV values among patients with HCC awaiting OLT provided valuable information regarding the effectiveness of TACE.
INTRODUCTION: The aim of this study was to analyze the correlation between 18-FDG positron emission tomography (PET)/computed tomography (CT), histological necrosis, and prognosis after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) patients undergoing orthotopic liver transplantation (OLT). PATIENTS: From January 2007 through December 2013, 81 patients with HCC and liver cirrhosis were included in our liver transplantation program. For this study we selected patients who underwent 18-FDG PET/CT pre-TACE and post-TACE. All patients underwent liver transplantation within 8 weeks after PET/CT. RESULTS: Twenty patients with a median age of 58 years (range, 46-69 years) underwent an 18-FDG PET/CT before and after TACE. The median Standardized Uptake Value (SUV) before TACE was 3.8 (range, 2.6-8.7), with a median post-TACE SUV of 0% (range, 0-4). Among patients whose post-TACE SUV decreased to <3, >70% necrosis was observed upon study of a hepatectomy sample, with a survival rate of 100% and 80% at 1 and 3 years, respectively. CONCLUSION: In conclusion, performance of an 18-FDG PET/CT before and after TACE with comparison of SUV values among patients with HCC awaiting OLT provided valuable information regarding the effectiveness of TACE.
Authors: Rohini Sharma; Marianna Inglese; Suraiya Dubash; Haonan Lu; David J Pinato; Chandan Sanghera; Neva Patel; Anthony Chung; Paul D Tait; Francesco Mauri; William R Crum; Tara D Barwick; Eric O Aboagye Journal: J Nucl Med Date: 2020-06-08 Impact factor: 10.057