Literature DB >> 26518563

Creation and study of triterpenoid nanoparticles and radioprotective substance genistein.

H Q Nguyen1, V V Chupin2, D I Prokhorov3, I E Chikunov4, V Yu Kovtun4, R A Tarumov5, A N Grebenyuk5, V I Shvets6.   

Abstract

This work is devoted to the study and obtaining of new radioprotective agents based on natural flavonoid genistein and spherical amorphous nanoparticles (SANPs) produced from a mixture of birch bark triterpenoids. The physicochemical characteristics of the nanoparticles were studied by electron microscopy, dynamic light scattering, and UV-VIS spectroscopy. The radioprotective efficacy of the nanodrug in vivo and the possibility of its use as a radioprotective agent was shown.

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Year:  2015        PMID： 26518563     DOI： 10.1134/S160767291505018X

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  3 in total

1.  [Creation and Study of Triterpenoid Nanoparticles and Amphiphilic meso-Arylporphyrins].

Authors:  H Q Nguyen; K A Zhdanova; V S Uvarova; N A Bragina; A F Mironov; V V Chupin; V I Svets
Journal:  Bioorg Khim       Date:  2015 Mar-Apr

2.  Genistein induces radioprotection by hematopoietic stem cell quiescence.

Authors:  Thomas A Davis; Ognoon Mungunsukh; Stephen Zins; Regina M Day; Michael R Landauer
Journal:  Int J Radiat Biol       Date:  2008-09       Impact factor: 2.694

3.  Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation.

Authors:  Regina M Day; Michal Barshishat-Kupper; Steven R Mog; Elizabeth A McCart; P G S Prasanna; Thomas A Davis; Michael R Landauer
Journal:  J Radiat Res       Date:  2008-04-23       Impact factor: 2.724
  3 in total

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