Literature DB >> 26518553

Proteolysis of His-Phe-Arg-Trp-Pro-Gly-Pro in the blood and brain of rats in vivo.

K V Shevchenko1, I Yu Nagaev2, V N Babakov3, L A Andreeva2, V P Shevchenko2, A S Radilov3, N F Myasoedov2.   

Abstract

The kinetics of the content of His-Phe-Arg-Trp-Pro-Gly-Pro (ACTH (6-9)PGP) and its hydrolysis products in the blood and brain of rats in the case of intranasal administration and intravenous injection of tritiated ACTH(6-9)PGP was studied. The parameters of bioavailability of ACTH(6-9)PGP administered intranasally were higher, indicating certain prospects in the intranasal application in clinical practice. We also found that the factor that determines ACTH(6-9)PGP proteolysis in experiments both in vivo and in vitro is aminopeptidases. The main products of ACTH(6-9)PGP during its metabolism in rats are short peptides and amino acids.

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Year:  2015        PMID： 26518553     DOI： 10.1134/S1607672915050087

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  3 in total

1.  Evaluation of direct transport pathways of glycine receptor antagonists and an angiotensin antagonist from the nasal cavity to the central nervous system in the rat model.

Authors:  Stuart T Charlton; Joanne Whetstone; Susan T Fayinka; Kevin D Read; Lisbeth Illum; Stanley S Davis
Journal:  Pharm Res       Date:  2008-02-22       Impact factor: 4.200

2.  Entry of the synthetic ACTH(4-10) analogue into the rat brain following intravenous injection.

Authors:  V N Potaman; L V Antonova; V A Dubynin; D A Zaitzev; A A Kamensky; N F Myasoedov; V N Nezavibatko
Journal:  Neurosci Lett       Date:  1991-06-10       Impact factor: 3.046

3.  [Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration].

Authors:  K V Shevchenko; I Iu Nagaev; L Iu Alfeeva; L A Andreeva; A A Kamenskiĭ; N G Levitskaia; V P Shevchenko; I A Grivennikov; N F Miasoedov
Journal:  Bioorg Khim       Date:  2006 Jan-Feb
  3 in total
  1 in total

1.  The penetration of 5-oxo-Pro-Arg-Pro into the brain and the major metabolic pathways of this peptide in the rat brain and blood at the intranasal and intravenous administration.

Authors:  K V Shevchenko; I Yu Nagaev; V P Shevchenko; L A Andreeva; S I Shram; N F Myasoedov
Journal:  Dokl Biochem Biophys       Date:  2017-05-17       Impact factor: 0.788
  1 in total

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