Literature DB >> 26518549

Longitudinal orientation of cross-linked polypeptide γ chains in fibrin fibrils.

M A Rosenfeld1, V B Leonova2, A V Bychkova2, E A Kostanova2, M I Biryukova2.   

Abstract

The crosslinking of fibrin γ-polypeptide chains under the influence of the plasma fibrin-stabilizing factor (FXIIIa), which causes their conversion to γ-γ dimers, is the major enzyme reaction of covalent fibrin stabilization. We studied the self-assembly of soluble cross-linked fibrin oligomers. The results of analytical ultracentrifugation as well as elastic and dynamic light scattering showed that the double-stranded fibrin oligomers formed under the influence of moderate concentrations of urea are cross-linked only due to formation of γ-γ dimers, which can dissociate into single-stranded structure when the concentration of urea increases. This fact proves that γ-γ dimers are formed in the end-to-end manner.

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Year:  2015        PMID： 26518549     DOI： 10.1134/S1607672915050051

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  13 in total

1.  Polymerization of rod-like macromolecular monomers studied by stopped-flow, multiangle light scattering: set-up, data processing, and application to fibrin formation.

Authors:  S Bernocco; F Ferri; A Profumo; C Cuniberti; M Rocco
Journal:  Biophys J       Date:  2000-07       Impact factor: 4.033

2.  Position of gamma-chain carboxy-terminal regions in fibrinogen/fibrin cross-linking mixtures.

Authors:  K R Siebenlist; D A Meh; M W Mosesson
Journal:  Biochemistry       Date:  2000-11-21       Impact factor: 3.162

Review 3.  Cross-linked gamma-chains in fibrin fibrils bridge transversely between strands: no.

Authors:  J W Weisel
Journal:  J Thromb Haemost       Date:  2004-03       Impact factor: 5.824

Review 4.  Cross-linked gamma-chains in fibrin fibrils bridge 'transversely' between strands: yes.

Authors:  M W Mosesson
Journal:  J Thromb Haemost       Date:  2004-03       Impact factor: 5.824

5.  Self-assembly of soluble unlinked and cross-linked fibrin oligomers.

Authors:  M A Rosenfeld; V B Leonova; M I Biryukova; M V Vasileva
Journal:  Biochemistry (Mosc)       Date:  2011-10       Impact factor: 2.487

6.  Ozone-induced oxidative modification of plasma fibrin-stabilizing factor.

Authors:  Mark A Rosenfeld; Anna V Bychkova; Alexander N Shchegolikhin; Vera B Leonova; Marina I Biryukova; Elizaveta A Kostanova
Journal:  Biochim Biophys Acta       Date:  2013-08-12

7.  The complementary aggregation sites of fibrin investigated through examination of polymers of fibrinogen with fragment E.

Authors:  Y Veklich; E K Ang; L Lorand; J W Weisel
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

8.  [Mechanism of self-assembly of soluble fibrin oligomers and the role of fibrinopeptides A and B in this process].

Authors:  M A Rozenfel'd; K B Gershkovich; D V Kuznetsov; B B Meshkov; I D Gontar'
Journal:  Mol Biol (Mosk)       Date:  1986 Jul-Aug

9.  The covalent structure of factor XIIIa crosslinked fibrinogen fibrils.

Authors:  M W Mosesson; K R Siebenlist; J F Hainfeld; J S Wall
Journal:  J Struct Biol       Date:  1995 Jul-Aug       Impact factor: 2.867

10.  Determination of the topology of factor XIIIa-induced fibrin gamma-chain cross-links by electron microscopy of ligated fragments.

Authors:  J W Weisel; C W Francis; C Nagaswami; V J Marder
Journal:  J Biol Chem       Date:  1993-12-15       Impact factor: 5.157
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