J S Carpenter1, N F Woods2, J L Otte1, K A Guthrie3, C Hohensee3, K M Newton4, H Joffe5, L Cohen6, B Sternfeld7, R J Lau8, S D Reed9, A Z LaCroix10. 1. a Science of Nursing Care, School of Nursing, Indiana University , Indianapolis , IN ; 2. b Biobehavioral Nursing, University of Washington , Seattle , WA ; 3. c Fred Hutchinson Cancer Research Center , Seattle , WA ; 4. d Group Health Research Institute , Seattle , WA ; 5. e Harvard Medical School, Department of Psychiatry , Brigham and Women's Hospital and Dana Farber Cancer Institute , Boston , MA ; 6. f Center for Women's Mental Health; Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital , Boston , MA ; 7. g Division of Research , Kaiser Permanent Medical Program of Northern California , Oakland , CA ; 8. h Department of Obstetrics and Gynecology , School of Medicine, Indiana University , Indianapolis , IN ; 9. i Departments of Obstetrics/Gynecology and Epidemiology , University of Washington School of Medicine , Seattle , WA ; 10. j Department of Preventive Medicine , University of California San Diego , San Diego , CA , USA.
Abstract
OBJECTIVE: To describe self-reported menopausal symptom priorities and their association with demographics and other symptoms among participants in an intervention trial for vasomotor symptoms (VMS). METHODS: Cross-sectional study embedded in the MsFLASH 02 trial, a three-by-two factorial design of yoga vs. exercise vs. usual activity and omega-3-fatty acid vs. placebo. At baseline, women (n = 354) completed hot flush diaries, a card sort task to prioritize symptoms they would most like to alleviate, and standardized questionnaires. RESULTS: The most common symptom priorities were: VMS (n = 322), sleep (n = 191), concentration (n = 140), and fatigue (n = 116). In multivariate models, women who chose VMS as their top priority symptom (n = 210) reported significantly greater VMS severity (p = 0.004) and never smoking (p = 0.012), and women who chose sleep as their top priority symptom (n = 100) were more educated (p ≤ 0.001) and had worse sleep quality (p < 0.001). ROC curves identified sleep scale scores that were highly predictive of ranking sleep as a top priority symptom. CONCLUSIONS: Among women entering an intervention trial for VMS and with relatively low prevalence of depression and anxiety, VMS was the priority symptom for treatment. A card sort may be a valid tool for quickly assessing symptom priorities in clinical practice and research.
OBJECTIVE: To describe self-reported menopausal symptom priorities and their association with demographics and other symptoms among participants in an intervention trial for vasomotor symptoms (VMS). METHODS: Cross-sectional study embedded in the MsFLASH 02 trial, a three-by-two factorial design of yoga vs. exercise vs. usual activity and omega-3-fatty acid vs. placebo. At baseline, women (n = 354) completed hot flush diaries, a card sort task to prioritize symptoms they would most like to alleviate, and standardized questionnaires. RESULTS: The most common symptom priorities were: VMS (n = 322), sleep (n = 191), concentration (n = 140), and fatigue (n = 116). In multivariate models, women who chose VMS as their top priority symptom (n = 210) reported significantly greater VMS severity (p = 0.004) and never smoking (p = 0.012), and women who chose sleep as their top priority symptom (n = 100) were more educated (p ≤ 0.001) and had worse sleep quality (p < 0.001). ROC curves identified sleep scale scores that were highly predictive of ranking sleep as a top priority symptom. CONCLUSIONS: Among women entering an intervention trial for VMS and with relatively low prevalence of depression and anxiety, VMS was the priority symptom for treatment. A card sort may be a valid tool for quickly assessing symptom priorities in clinical practice and research.
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