| Literature DB >> 26517392 |
Lin Yang1, Zhen Wang2, Yu Shi3, Jingguang Li4, Yuxin Wang3, Yunfeng Zhao3, Yongning Wu3, Zongwei Cai5.
Abstract
Perfluoroalkyl acids (PFAAs) precursors, the indirect source of PFAA exposure, have been observed in environmental and human samples. However, the maternal-fetal transfer of these chemicals has not been well examined. In this study, 50 paired maternal and cord serum samples collected in Jiangsu province of China were analyzed for fifteen PFAA precursors. Among the detected PFAAs, 6:2 fluorotelomer sulfonate (6:2 FTS), N-methyl- and N-ethyl-perfluorooctanesulfonamidoacetates had comparable detection rate in both maternal and cord sera, while the mean concentrations and detection rates of 8:2 FTS and perfluorooctane sulfonamide (PFOSA) were higher in maternal sera compared to cord sera (Mann-Whitney U test, P < 0.05). Analysis of variance and least significant difference tests showed that the youngest maternal age group (21-24 years old) had the highest concentration of 6:2 FTS in cord sera. Maternal serum PFOSA was found significantly correlated with the cord serum perfluorooctanesulfonate (PFOS) (Spearman test, r = 0.361, P = 0.010), indicating that maternal serum PFOSA might be an indirect source of PFOS in fetuses. The obtained results suggested the potential prenatal exposure and human placental transfer of perfluoroalkyl acid precursors.Entities:
Keywords: Perfluoroalkyl acids; Placenta transfer; Precursors; Prenatal exposure; Serum analysis
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Year: 2015 PMID： 26517392 DOI： 10.1016/j.chemosphere.2015.10.063
Source DB: PubMed Journal: Chemosphere ISSN： 0045-6535 Impact factor: 7.086