Literature DB >> 26517303

Synthesis and In Vivo PET Imaging of Hyaluronan Conjugates of Oligonucleotides.

Satish Jadhav1, Meeri Käkelä, Jussi Mäkilä, Max Kiugel, Heidi Liljenbäck, Jenni Virta, Päivi Poijärvi-Virta1, Tiina Laitala-Leinonen, Ville Kytö, Sirpa Jalkanen, Antti Saraste, Anne Roivainen, Harri Lönnberg1, Pasi Virta1.   

Abstract

Synthesis for (68)Ga-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-chelated oligonucleotide hyaluronan (HA) tetra- and hexasaccharide conjugates is described. A solid-supported technique is used to introduce NOTA-chelator into the 3'-terminus of oligonucleotides and a copper-free strain promoted azide alkyne cycloaddition (SPAAC) to HA/oligonucleotide conjugation. Protecting group manipulation, required for the HA-moieties, is carried out after the SPAAC-conjugation. Positron emission tomography (PET) is used (1) in the whole-body distribution kinetic studies of the conjugates in healthy rats and (2) to show the potential of hyaluronan-induced targeting of oligonucleotides into the infarcted area of rats with myocardial infarction.

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Year:  2015        PMID： 26517303     DOI： 10.1021/acs.bioconjchem.5b00477

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  5 in total

1.  Adventures in radiosynthesis of clinical grade [68Ga]Ga-DOTA-Siglec-9.

Authors:  Meeri Käkelä; Pauliina Luoto; Tapio Viljanen; Helena Virtanen; Heidi Liljenbäck; Sirpa Jalkanen; Juhani Knuuti; Anne Roivainen; Xiang-Guo Li
Journal:  RSC Adv       Date:  2018-02-20       Impact factor: 4.036

Review 2.  Prospective of 68Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation.

Authors:  Irina Velikyan
Journal:  Contrast Media Mol Imaging       Date:  2018-01-04       Impact factor: 3.161

3.  Synthesis of Azide-Modified Chondroitin Sulfate Precursors: Substrates for "Click"- Conjugation with Fluorescent Labels and Oligonucleotides.

Authors:  Satish Jadhav; Vijay Gulumkar; Prasannakumar Deshpande; Eleanor T Coffey; Harri Lönnberg; Pasi Virta
Journal:  Bioconjug Chem       Date:  2018-06-15       Impact factor: 4.774

4.  Noninvasive and Quantitative Monitoring of the Distributions and Kinetics of MicroRNA-Targeting Molecules in Vivo by Positron Emission Tomography.

Authors:  Jussi Mäkilä; Anu Kiviniemi; Tiina Saanijoki; Heidi Liljenbäck; Meeri Käkelä; Satish Jadhav; Päivi Poijärvi-Virta; Harri Lönnberg; Tiina Laitala-Leinonen; Pasi Virta; Anne Roivainen
Journal:  Mol Pharm       Date:  2019-03-22       Impact factor: 4.939

5.  Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice In Vivo.

Authors:  Ravindra Dhar Dubey; Rebecca Klippstein; Julie Tzu-Wen Wang; Naomi Hodgins; Kuo-Ching Mei; Jane Sosabowski; Robert C Hider; Vincenzo Abbate; Prem N Gupta; Khuloud T Al-Jamal
Journal:  Nanotheranostics       Date:  2017-01-01
  5 in total

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