INTRODUCTION: In this study, the molecular characteristics of group A rotavirus (RVA) were compared in samples obtained before and after RVA vaccine-introduction in Brazil. METHODS: Eighty samples were screened for the presence of RVA. Positive samples were molecularly analyzed. RESULTS: RVA positivity was 16.9%, with a predominance of G2P[4]. Periods: pre-vaccination: predominance of IId (G1), IId (G2) lineages, and I1 and E1 genotypes; post-vaccination: predominance of Ib (G1), IIa, and IIc (G2) lineages and I2 and E2 genotypes. CONCLUSIONS: Although changes in RVA-circulation pattern were observed in the post-vaccination period, it could not be attributed to vaccination process.
INTRODUCTION: In this study, the molecular characteristics of group A rotavirus (RVA) were compared in samples obtained before and after RVA vaccine-introduction in Brazil. METHODS: Eighty samples were screened for the presence of RVA. Positive samples were molecularly analyzed. RESULTS:RVA positivity was 16.9%, with a predominance of G2P[4]. Periods: pre-vaccination: predominance of IId (G1), IId (G2) lineages, and I1 and E1 genotypes; post-vaccination: predominance of Ib (G1), IIa, and IIc (G2) lineages and I2 and E2 genotypes. CONCLUSIONS: Although changes in RVA-circulation pattern were observed in the post-vaccination period, it could not be attributed to vaccination process.
Authors: Betty E Owor; Mike J Mwanga; Regina Njeru; Robert Mugo; Mwanajuma Ngama; Grieven P Otieno; D J Nokes; C N Agoti Journal: Wellcome Open Res Date: 2019-05-15