| Literature DB >> 26516761 |
Fernando Agüero1, Alejandro Forner2,3, Christian Manzardo1, Andres Valdivieso4,5, Marino Blanes6, Rafael Barcena7, Antoni Rafecas8, Lluis Castells3,9, Manuel Abradelo10, Julian Torre-Cisneros11, Luisa Gonzalez-Dieguez12, Magdalena Salcedo13, Trinidad Serrano14, Miguel Jimenez-Perez15, Jose Ignacio Herrero3,16,17, Mikel Gastaca4,5, Victoria Aguilera3,6, Juan Fabregat8, Santos Del Campo7, Itxarone Bilbao9, Carlos Jimenez Romero10, Asuncion Moreno1, Antoni Rimola3,18, Jose M Miro1.
Abstract
UNLABELLED: The impact of human immunodeficiency virus (HIV) infection on patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) is uncertain. This study aimed to assess the outcome of a prospective Spanish nationwide cohort of HIV-infected patients undergoing LT for HCC (2002-2014). These patients were matched (age, gender, year of LT, center, and hepatitis C virus (HCV) or hepatitis B virus infection) with non-HIV-infected controls (1:3 ratio). Patients with incidental HCC were excluded. Seventy-four HIV-infected patients and 222 non-HIV-infected patients were included. All patients had cirrhosis, mostly due to HCV infection (92%). HIV-infected patients were younger (47 versus 51 years) and had undetectable HCV RNA at LT (19% versus 9%) more frequently than non-HIV-infected patients. No significant differences were detected between HIV-infected and non-HIV-infected recipients in the radiological characteristics of HCC at enlisting or in the histopathological findings for HCC in the explanted liver. Survival at 1, 3, and 5 years for HIV-infected versus non-HIV-infected patients was 88% versus 90%, 78% versus 78%, and 67% versus 73% (P = 0.779), respectively. HCV infection (hazard ratio = 7.90, 95% confidence interval 1.07-56.82) and maximum nodule diameter >3 cm in the explanted liver (hazard ratio = 1.72, 95% confidence interval 1.02-2.89) were independently associated with mortality in the whole series. HCC recurred in 12 HIV-infected patients (16%) and 32 non-HIV-infected patients (14%), with a probability of 4% versus 5% at 1 year, 18% versus 12% at 3 years, and 20% versus 19% at 5 years (P = 0.904). Microscopic vascular invasion (hazard ratio = 3.40, 95% confidence interval 1.34-8.64) was the only factor independently associated with HCC recurrence.Entities:
Mesh：
Year: 2016 PMID： 26516761 DOI： 10.1002/hep.28321
Source DB: PubMed Journal: Hepatology ISSN： 0270-9139 Impact factor: 17.425