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Literature DB >> 26516521

Human pain and genetics: some basics.

Abstract

Human pain causes untold misery and suffering, with major impact on functioning and resources. Recent advances in genetics have revealed that subtle changes in DNA could partly explain the variation in individual differences in pain. Various genes encoding for receptors are now known to play a major role in the sensitivity, perception and expression of pain. The fields of epigenetics and proteomics hold promises in the way pain could be treated and managed in future.

Entities: Disease Species

Keywords: Chronic pain; congenital; fibromyalgia; genetics; hereditary sensory and autonomic neuropathies; musculoskeletal pain; nociceptive pain; pain; pain insensitivity; pain perception; post-operative; temporomandibular joint dysfunction syndrome

Year: 2013 PMID： 26516521 PMCID： PMC4590159 DOI： 10.1177/2049463713506408

Source DB: PubMed Journal: Br J Pain ISSN： 2049-4637

53 in total

1. Gene therapy for pain: results of a phase I clinical trial.

Authors: David J Fink; James Wechuck; Marina Mata; Joseph C Glorioso; James Goss; David Krisky; Darren Wolfe
Journal: Ann Neurol Date: 2011-07-27 Impact factor: 10.422

2. Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: results from the 1958 British Birth Cohort Study.

Authors: Lynne J Hocking; Blair H Smith; Gareth T Jones; David M Reid; David P Strachan; Gary J Macfarlane
Journal: Pain Date: 2010-02-18 Impact factor: 6.961

3. Differences in postoperative pain severity among four ethnic groups.

Authors: J Faucett; N Gordon; J Levine
Journal: J Pain Symptom Manage Date: 1994-08 Impact factor: 3.612

4. Psychophysical and EEG responses to repeated experimental muscle pain in humans: pain intensity encodes EEG activity.

Authors: Peng-Fei Chang; Lars Arendt-Nielsen; Thomas Graven-Nielsen; Andrew C N Chen
Journal: Brain Res Bull Date: 2003-02-15 Impact factor: 4.077

5. Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.

Authors: Irmgard Tegeder; Jan Adolph; Helmut Schmidt; Clifford J Woolf; Gerd Geisslinger; Jörn Lötsch
Journal: Eur J Pain Date: 2008-04-18 Impact factor: 3.931

6. A single-nucleotide polymorphism in SCN9A may decrease postoperative pain sensitivity in the general population.

Authors: Guangyou Duan; Guifang Xiang; Xianwei Zhang; Ruimei Yuan; Huiming Zhan; Dongmei Qi
Journal: Anesthesiology Date: 2013-02 Impact factor: 7.892

Review 7. A human trial of HSV-mediated gene transfer for the treatment of chronic pain.

Authors: D Wolfe; M Mata; D J Fink
Journal: Gene Ther Date: 2009-02-26 Impact factor: 5.250

8. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.

Authors: Andrea Gail Nackley; Kai Soo Tan; Karamarie Fecho; Patrick Flood; Luda Diatchenko; William Maixner
Journal: Pain Date: 2006-11-07 Impact factor: 7.926

9. Gene therapy: a potential approach for cancer pain.

Authors: Chalonda R Handy; Christina Krudy; Nicholas Boulis
Journal: Pain Res Treat Date: 2011-06-09

Review 10. Overview of the voltage-gated sodium channel family.

Authors: Frank H Yu; William A Catterall
Journal: Genome Biol Date: 2003-02-24 Impact factor: 13.583

14 in total

1. Splice variation of the mu-opioid receptor and its effect on the action of opioids.

Authors: Sophy K Gretton; Joanne Droney
Journal: Br J Pain Date: 2014-11

Review 2. Chronic pain: a review of its epidemiology and associated factors in population-based studies.

Authors: Sarah E E Mills; Karen P Nicolson; Blair H Smith
Journal: Br J Anaesth Date: 2019-05-10 Impact factor: 9.166

3. C57BL/6 substrain differences in formalin-induced pain-like behavioral responses.

Authors: Esad Ulker; Martial Caillaud; Trusha Patel; Alyssa White; Danyal Rashid; Mashael Alqasem; Aron H Lichtman; Camron D Bryant; M Imad Damaj
Journal: Behav Brain Res Date: 2020-05-16 Impact factor: 3.332

4. Chronic postsurgical pain: is there a possible genetic link?

Authors: Sabu Kumar James
Journal: Br J Pain Date: 2017-07-28

Review 5. Pharmacogenomics of Pain Management: The Impact of Specific Biological Polymorphisms on Drugs and Metabolism.

Authors: Elyse M Cornett; Michelle A Carroll Turpin; Allison Pinner; Pankaj Thakur; Tamizh Selvan Gnana Sekaran; Harish Siddaiah; Jasmine Rivas; Anna Yates; G Jason Huang; Anitha Senthil; Narjeet Khurmi; Jenna L Miller; Cain W Stark; Richard D Urman; Alan David Kaye
Journal: Curr Oncol Rep Date: 2020-02-06 Impact factor: 5.075

10. Development of an AmpliSeq^TM Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain.

Authors: Dario Kringel; Mari A Kaunisto; Catharina Lippmann; Eija Kalso; Jörn Lötsch
Journal: Front Pharmacol Date: 2018-09-19 Impact factor: 5.810