Ozlem Celebi1, Andac Uzdogan2, Kader Karli Oguz3, Arzu Ceylan Has4, Anil Dolgun5, Gul Yalcin Cakmakli1, Filiz Akbiyik2, Bulent Elibol6, Esen Saka7. 1. Hacettepe University, Institute of Health Sciences, Department of Neurological Sciences and Psychiatry, Ankara, Turkey. 2. Hacettepe University Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey. 3. Hacettepe University Faculty of Medicine, Department of Radiology, Ankara, Turkey. 4. Bilkent University, National Magnetic Resonance Research Center, Ankara, Turkey. 5. Hacettepe University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey. 6. Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey. 7. Hacettepe University Faculty of Medicine, Department of Neurology, Ankara, Turkey. Electronic address: esensaka@hacettepe.edu.tr.
Abstract
BACKGROUND: Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific Aβ pathology. METHODS: Cognitive profiles; DMN connectivity alterations; and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, total tau, phosphorylated tau 181, and α-synuclein levels were studied in 21 patients with AD and 10 controls. RESULTS: DMN activity is altered in AD. Posterior cingulate cortex (PCC) functional connectivity with other parts of DMN was related to cognitive function scores. The reduction of connectivity of the dorsal PCC with the retrosplenial cortex on the right side was closely related to decreased CSF Aβ1-42 levels in patients with AD. CONCLUSIONS: The dorsal PCC and retrosplenial cortex may have special importance in the pathogenesis and cognitive findings of AD.
BACKGROUND: Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific Aβ pathology. METHODS: Cognitive profiles; DMN connectivity alterations; and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, total tau, phosphorylated tau 181, and α-synuclein levels were studied in 21 patients with AD and 10 controls. RESULTS: DMN activity is altered in AD. Posterior cingulate cortex (PCC) functional connectivity with other parts of DMN was related to cognitive function scores. The reduction of connectivity of the dorsal PCC with the retrosplenial cortex on the right side was closely related to decreased CSF Aβ1-42 levels in patients with AD. CONCLUSIONS: The dorsal PCC and retrosplenial cortex may have special importance in the pathogenesis and cognitive findings of AD.
Authors: Hai Rong Ma; Ping Lei Pan; Li Qin Sheng; Zhen Yu Dai; Gen Di Wang; Rong Luo; Jia Hui Chen; Pei Rong Xiao; Jian Guo Zhong; Hai Cun Shi Journal: Oncotarget Date: 2017-10-04