The contribution of alveolar macrophages to hyperreactive airway disease.

Thus, there is substantial evidence that favors a role for macrophages in subjects with atopic asthma. The precise manner in which these cells participate and the relative degree to which these cells contribute to, or orchestrate, events remains to be delineated. Research on the potential role of macrophages in asthma syndromes remains in its infancy. In time we will discover new roles for mononuclear phagocyte-derived mediators and many more new mediators that will play a role in the complex immunologic events ongoing in the airways of patients with asthma. Also, future research will continue to explore what promises to be a productive area of research, namely, cell-cell interactions and the manner in which many cells participate together in the pathophysiology of asthma. If macrophages can be demonstrated to influence airway inflammation associated with atopic disease, they may be appropriate targets for therapeutic intervention.