Literature DB >> 26515018

RNF138 joins the HR team.

Simon Bekker-Jensen1, Niels Mailand1.   

Abstract

Two studies show that the E3 ubiquitin ligase RNF138 is recruited to DNA double-strand break sites, where it ubiquitylates key repair factors to promote DNA-end resection and homologous recombination. These findings add insights into the multilayered regulatory mechanisms underlying DNA double-strand break repair pathway choice in mammalian cells.

Entities:  

Year:  2015        PMID： 26515018     DOI： 10.1038/ncb3262

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

1.  The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice.

Authors:  Ismail Hassan Ismail; Jean-Philippe Gagné; Marie-Michelle Genois; Hilmar Strickfaden; Darin McDonald; Zhizhong Xu; Guy G Poirier; Jean-Yves Masson; Michael J Hendzel
Journal:  Nat Cell Biol       Date:  2015-10-26       Impact factor: 28.824

Review 2.  CtIP: A DNA damage response protein at the intersection of DNA metabolism.

Authors:  Nodar Makharashvili; Tanya T Paull
Journal:  DNA Repair (Amst)       Date:  2015-05-02

3.  Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.

Authors:  Andrew E H Elia; Alexander P Boardman; David C Wang; Edward L Huttlin; Robert A Everley; Noah Dephoure; Chunshui Zhou; Itay Koren; Steven P Gygi; Stephen J Elledge
Journal:  Mol Cell       Date:  2015-06-04       Impact factor: 17.970

Review 4.  The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.

Authors:  Michael R Lieber
Journal:  Annu Rev Biochem       Date:  2010       Impact factor: 23.643

5.  Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.

Authors:  Lou K Povlsen; Petra Beli; Sebastian A Wagner; Sara L Poulsen; Kathrine B Sylvestersen; Jon W Poulsen; Michael L Nielsen; Simon Bekker-Jensen; Niels Mailand; Chunaram Choudhary
Journal:  Nat Cell Biol       Date:  2012-09-23       Impact factor: 28.824

Review 6.  Should I stay or should I go: VCP/p97-mediated chromatin extraction in the DNA damage response.

Authors:  Nico P Dantuma; Klara Acs; Martijn S Luijsterburg
Journal:  Exp Cell Res       Date:  2014-08-27       Impact factor: 3.905

Review 7.  Regulation of DNA damage responses by ubiquitin and SUMO.

Authors:  Stephen P Jackson; Daniel Durocher
Journal:  Mol Cell       Date:  2013-02-14       Impact factor: 17.970

8.  Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.

Authors:  Christine K Schmidt; Yaron Galanty; Matylda Sczaniecka-Clift; Julia Coates; Satpal Jhujh; Mukerrem Demir; Matthew Cornwell; Petra Beli; Stephen P Jackson
Journal:  Nat Cell Biol       Date:  2015-10-26       Impact factor: 28.824

9.  Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.

Authors:  Yasuhiro Murakawa; Eiichiro Sonoda; Louise J Barber; Weihua Zeng; Kyoko Yokomori; Hiroshi Kimura; Atsuko Niimi; Alan Lehmann; Guang Yu Zhao; Helfrid Hochegger; Simon J Boulton; Shunichi Takeda
Journal:  Cancer Res       Date:  2007-09-15       Impact factor: 12.701

10.  Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.

Authors:  Ryotaro Nishi; Paul Wijnhoven; Carlos le Sage; Jorrit Tjeertes; Yaron Galanty; Josep V Forment; Michael J Clague; Sylvie Urbé; Stephen P Jackson
Journal:  Nat Cell Biol       Date:  2014-09-07       Impact factor: 28.824
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  3 in total

1.  The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining.

Authors:  Fangzhou Li; Qianqian Sun; Kun Liu; Haichao Han; Ning Lin; Zhongyi Cheng; Yueming Cai; Feng Tian; Zebin Mao; Tanjun Tong; Wenhui Zhao
Journal:  Cell Mol Life Sci       Date:  2019-04-12       Impact factor: 9.261

2.  RING finger 138 deregulation distorts NF-кB signaling and facilities colitis switch to aggressive malignancy.

Authors:  Yalan Lu; Rong Huang; Jianming Ying; Xingchen Li; Tao Jiao; Lei Guo; Haitao Zhou; Han Wang; Amannisa Tuersuntuoheti; Jianmei Liu; Qichen Chen; Yanhong Wang; Luying Su; Changyuan Guo; Fu Xu; Ziyi Wang; Yan Lu; Kai Li; Junbo Liang; Zhen Huang; Xiao Chen; Jinjie Yao; Hanjie Hu; Xiaowen Cheng; Yufeng Wan; Xinyan Chen; Ning Zhang; Shiying Miao; Jianqiang Cai; Linfang Wang; Changzheng Liu; Wei Song; Hong Zhao
Journal:  Signal Transduct Target Ther       Date:  2022-06-13

Review 3.  Controlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMO.

Authors:  Sarah-Felicitas Himmels; Alessandro A Sartori
Journal:  Front Genet       Date:  2016-08-23       Impact factor: 4.599
  3 in total

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