Efstratios Koutroumpakis1, Claudia Ramos-Rivers2, Miguel Regueiro3, Jana G Hashash4, Arthur Barrie5, Jason Swoger6, Leonard Baidoo7, Marc Schwartz8, Michael A Dunn9, Ioannis E Koutroubakis10, David G Binion11. 1. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. skoutroubakis@gmail.com. 2. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. cmr95@pitt.edu. 3. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. mdr7@pitt.edu. 4. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. alhashashj@upmc.edu. 5. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. amb145@pitt.edu. 6. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. swogerjm@upmc.edu. 7. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. lkb19@pitt.edu. 8. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. mbs53@pitt.edu. 9. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. dunnma@upmc.edu. 10. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. ikoutroub@med.uoc.gr. 11. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, 200 Lothrop Street PUH Mezzanine Level C Wing, Pittsburgh, PA, 15213, USA. biniond@upmc.edu.
Abstract
BACKGROUND: Inflammatory bowel disease (IBD) has been linked to an increased risk of coronary heart disease and stroke. Dyslipidemia is a well-established risk factor for cardiovascular disease. The aim of this study was to investigate the long-term lipid profiles in a large cohort of IBD patients. METHODS: Data of patients from an IBD registry who had more than one measurement of total cholesterol and triglyceride levels during the follow-up period were analyzed. The lipid profiles of IBD patients were compared to those of the general population according to National Health and Nutrition Examination Survey (2009-2012). Quartiles of cholesterol or triglyceride levels in relation to surrogate markers of disease severity were analyzed. RESULTS: Seven hundred and one IBD patients [54% Crohn's disease (CD), 46% ulcerative colitis (UC)] were included. IBD patients had less frequent high total cholesterol and high LDL cholesterol (6 vs. 13 and 5 vs. 10%) and more frequent low HDL and high triglycerides (24 vs. 17 and 33 vs. 25%) compared to the general population (all p < 0.001). Median total cholesterol levels were lower and median triglycerides higher in CD compared to UC (171 vs. 184; 123 vs. 100 mg/dL; both p < 0.001). In the multiple regression analysis, lipid profile was independently associated with hospitalizations (low cholesterol) and IBD surgeries (low cholesterol and high triglycerides). CONCLUSIONS: Low total cholesterol and high triglyceride levels are more frequent in IBD patients (in particular CD) compared to healthy controls and are independently associated with more severe disease.
BACKGROUND:Inflammatory bowel disease (IBD) has been linked to an increased risk of coronary heart disease and stroke. Dyslipidemia is a well-established risk factor for cardiovascular disease. The aim of this study was to investigate the long-term lipid profiles in a large cohort of IBDpatients. METHODS: Data of patients from an IBD registry who had more than one measurement of total cholesterol and triglyceride levels during the follow-up period were analyzed. The lipid profiles of IBDpatients were compared to those of the general population according to National Health and Nutrition Examination Survey (2009-2012). Quartiles of cholesterol or triglyceride levels in relation to surrogate markers of disease severity were analyzed. RESULTS: Seven hundred and one IBDpatients [54% Crohn's disease (CD), 46% ulcerative colitis (UC)] were included. IBDpatients had less frequent high total cholesterol and high LDL cholesterol (6 vs. 13 and 5 vs. 10%) and more frequent low HDL and high triglycerides (24 vs. 17 and 33 vs. 25%) compared to the general population (all p < 0.001). Median total cholesterol levels were lower and median triglycerides higher in CD compared to UC (171 vs. 184; 123 vs. 100 mg/dL; both p < 0.001). In the multiple regression analysis, lipid profile was independently associated with hospitalizations (low cholesterol) and IBD surgeries (low cholesterol and high triglycerides). CONCLUSIONS: Low total cholesterol and high triglyceride levels are more frequent in IBDpatients (in particular CD) compared to healthy controls and are independently associated with more severe disease.
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