Hamideh Khazraiyan1, Zahra Abdi Liaei1, Hamid Emadi Koochak1, Farid Azmoudeh Ardalan2, Zahra Ahmadinejad1, Ahmad Soltani3. 1. Department of Infectious Disease, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 3. Department of Disaster Public Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran a_soltani@razi.tums.ac.ir.
Abstract
BACKGROUND: The authors aimed to compare TST with QuantiFERON-TB Gold In-Tube (QFT) for detecting latent tuberculosis infection (LTBI) in HIV-infected patients in Iran as a TB-medium endemic country. METHODS: In a cross-sectional design,130 HIV-positive patients in HIV clinic of Tehran University were studied. Patients screened for LTBI with QFT and TST simultaneously. Concordance between 2 tests results and variables associated with tests discordance were assessed. RESULTS: Positive results found in 24.6% for TST and 7.7% for QFT. Overall agreement between them was 73.85% (Kappa = 0.083). History of imprisonment was associated with more positive TST (P = 0.014) and QFT (P = 0.01). Patients with intravenous drug use (IDU) history had significant discordant results (0.018). CONCLUSION: The authors recommend QFT for all negative cases of TST in HIV-positive patients especially who had history of IDU.
BACKGROUND: The authors aimed to compare TST with QuantiFERON-TB Gold In-Tube (QFT) for detecting latent tuberculosis infection (LTBI) in HIV-infectedpatients in Iran as a TB-medium endemic country. METHODS: In a cross-sectional design,130 HIV-positivepatients in HIV clinic of Tehran University were studied. Patients screened for LTBI with QFT and TST simultaneously. Concordance between 2 tests results and variables associated with tests discordance were assessed. RESULTS: Positive results found in 24.6% for TST and 7.7% for QFT. Overall agreement between them was 73.85% (Kappa = 0.083). History of imprisonment was associated with more positive TST (P = 0.014) and QFT (P = 0.01). Patients with intravenous drug use (IDU) history had significant discordant results (0.018). CONCLUSION: The authors recommend QFT for all negative cases of TST in HIV-positivepatients especially who had history of IDU.