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Literature DB >> 26514622

TRIM-NHL proteins in development and disease.

Abstract

TRIM-NHL proteins are key regulators of developmental transitions, for example promoting differentiation, while inhibiting cell growth and proliferation, in stem and progenitor cells. Abnormalities in these proteins have been also associated with human diseases, particularly affecting muscular and neuronal functions, making them potential targets for therapeutic intervention. The purpose of this review is to provide a systematic and comprehensive summary on the most studied TRIM-NHL proteins, highlighting examples where connections were established between structural features, molecular functions and biological outcomes.

Entities: Gene Species

Keywords: Bardet-Biedl syndrome; Brat; LIN-41; Limb girdle muscular dystrophy 2H; Mei-P26; NHL; Sarcotubular myopathy; TRIM; TRIM32; TRIM71

Mesh：

Substances：

Year: 2015 PMID： 26514622 DOI： 10.1016/j.semcdb.2015.10.017

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

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Cited

38 in total

1. Gene expression-phenotype associations in adults with eosinophilic esophagitis.

Authors: Evan S Dellon; Sara R Selitsky; Robert M Genta; Richard H Lash; Joel S Parker
Journal: Dig Liver Dis Date: 2018-03-27 Impact factor: 4.088

Review 2. TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses.

Authors: Martina Di Rienzo; Alessandra Romagnoli; Manuela Antonioli; Mauro Piacentini; Gian Maria Fimia
Journal: Cell Death Differ Date: 2020-01-22 Impact factor: 15.828

3. TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1.

Authors: Katrine Stange Overå; Juncal Garcia-Garcia; Zambarlal Bhujabal; Ashish Jain; Aud Øvervatn; Kenneth Bowitz Larsen; Vojo Deretic; Terje Johansen; Trond Lamark; Eva Sjøttem
Journal: J Cell Sci Date: 2019-12-02 Impact factor: 5.285

4. The ubiquitin ligase tripartite-motif-protein 32 is induced in Duchenne muscular dystrophy.

Authors: Stefania Assereto; Rosanna Piccirillo; Serena Baratto; Paolo Scudieri; Chiara Fiorillo; Manuela Massacesi; Monica Traverso; Luis J Galietta; Claudio Bruno; Carlo Minetti; Federico Zara; Elisabetta Gazzerro
Journal: Lab Invest Date: 2016-06-13 Impact factor: 5.662

5. Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth.

Authors: Simranjot Bawa; David S Brooks; Kathryn E Neville; Marla Tipping; Md Abdul Sagar; Joseph A Kollhoff; Geetanjali Chawla; Brian V Geisbrecht; Jason M Tennessen; Kevin W Eliceiri; Erika R Geisbrecht
Journal: Elife Date: 2020-03-30 Impact factor: 8.140

10. Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.

Authors: Fang He; Zheqian Wu; Yong Wang; Lili Yin; Shijie Lu; Lihua Dai
Journal: Cell Biol Int Date: 2021-11-10 Impact factor: 4.473

TRIM-NHL proteins in development and disease.

1. Gene expression-phenotype associations in adults with eosinophilic esophagitis.

Review 2. TRIM proteins in autophagy: selective sensors in cell damage and innate immune responses.

3. TRIM32, but not its muscular dystrophy-associated mutant, positively regulates and is targeted to autophagic degradation by p62/SQSTM1.

4. The ubiquitin ligase tripartite-motif-protein 32 is induced in Duchenne muscular dystrophy.

5. Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth.

6. WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila.

Review 7. Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity.

Review 8. Molecular and biological functions of TRIM-NHL RNA-binding proteins.

Review 9. Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class.

10. Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.